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The Impact of Ozone on the Physical and Chemical Properties of Medical Foam and Semipermeable Membrane

Author: YinHaiLei
Tutor: CaiJinFang
School: Second Military Medical University
Course: Surgery
Keywords: Negative pressure wound therapy Medical sponge Semipermeable membrane Ozone
CLC: R318.08
Type: PhD thesis
Year: 2010
Downloads: 112
Quote: 1
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Abstract

Background: The negative pressure wound therapy (negative pressure Wound therapy, NPWT) in recent years is the rise of a new type of method to accelerate wound healing in patients. In practical applications, the first multi-side hole drainage tubes, medical sponge wrapped closed drainage outside the mouth or draining wound, and then the paste film (semi-permeable semipermeable membrane) connected to a negative pressure source, to form a highly efficient drainage system. NPWT used medical sponges mainly the sponge two kinds of polyurethane PU (Polyurethane), and polyvinyl esters, PVA (Polyvinyl alcohol). NPWT can early will open wound becomes closed wound lesions isolated to keep the local was a sealed vacuum state, prevent external bacteria invade; sponge dressing continuous negative pressure drainage, not easy plugging holes formed by the record-oriented dressing slow liquid flow of tissue fluid exudation after dressing filter vitality adsorbed on the organization of the tissue cells are retained, and lose the vitality of tissue cells and tissue fluid such as waste through the silicone tube suction, thus reducing bacterial survival and reproduction of the medium . Immediate drainage of the lesion exudate, obliteration of dead space, remove the hematoma; increased significantly strong negative pressure, the blood supply of the lesions, granulation tissue growth. Meanwhile, ozone sterilization rapid disinfection occurs in an instant. Has been widely used in clinical, such as air sterilization, intrauterine infection, dental infection treatment; ozone on the human body, especially respiratory poison, so the need to develop a closed system to avoid leaks, avoid the use of the process of poisoning occurred. According to the above two points, we proposed ozone negative pressure wound therapy (Ozone Negative Pressure Wound Therapy, ONPWT) envisaged: that closed suction cover the short-term alternative skin tissue; short-term confined the isolated air pollution, and reduce the opportunity of cross-infection. ; accelerate the infected necrotic tissue loss, reduce secretions, effective infection control, and promote the growth of granulation and wound healing. Wounds were covered, while the use of ozone as a fungicide to prevent wound infection; at the same time to kill the infected wounds harmful microorganisms, improve wounds oxygen, and promote wound healing. But ozone has strong oxidizing and corrosive addition to gold and platinum, the ozone almost all metal corrosive effect, also have a corrosive effect on the sponge and semi-permeable membrane material, and therefore need to select the anti-ozone oxidation and histocompatibility the material, the application of negative pressure in the ozone sealed suction system. Objective: To study the different concentrations of ozone water a medical sponge material and the physical and chemical properties of thin film materials, looking for sponges and thin film materials that can withstand ozone. Methods: The study is divided into three parts. The first part: choose a medical polyurethane sponge (the Shanghai Ying Lang Technology Co., Ltd.) and polyvinyl alcohol medical sponge (Wuhan Davis Medical Technology Co., Ltd.). Rinsed in vitro ozone negative pressure model, a sponge material was placed on the glass, the ends were indwelling flush pipe and suction pipe, of Anshu properly use British SN produced a transparent film hermetically sealed fixed sponge, rinse tube connected on the glass a homemade ozone water generator, the drainage tube connected to a suction device. Different concentrations of ozone water rinse time: 5min, 20min, 40min, the sponge material before and after the detection rinse performance. WDW-10 electronic universal testing machine according to GB / T 6344-2008 standard, ozone water rinse before and after the physical properties of the sponge (including stretching process maximum load, the specimen fracture instantly spacing). The change of the use of laser Raman spectroscopy test flushing before and after spectra analysis of whether changes in the chemical structure of the sponge. Part II: the of Anshu properly choose Britain SN semipermeable membranes, in vitro ozone negative pressure flush model, the sponge material is placed on the glass, the ends were indwelling the flushing pipe and the suction pipe, using Anshu duly transparent film enclosed the seal fixed sponge in the glass, rinse Pipe a homemade ozone water generator, drainage tube connected to a suction device. The different concentrations of ozone water rinse at different time, the performance of the wash before and after the thin film material is detected. According to GB / T 16578-1996 standard test film tear resistance. Raman spectroscopy the test rinse before and after spectrum the changes to the analysis of thin-film chemical structure of any change. Part III: in vitro model of ozone negative pressure rinse after the infusion of 4 mg / L ozone water for 5min 10mmin after 15min, ozone water sucked out of the determination of the time variation of the concentration of ozone water. Results: The first part: 4mg / L ozone water rinse 20min or 10mg of ozone water rinse 5min, no change in the physical properties of the polyurethane medical sponge. 4mg / L ozone water rinse 40min; 20min 10 mg ozone water rinse; 30mg / L the oxygen water rinse 5min, polyvinyl medical sponge physical properties (including the maximum load of the stretching process, no change in specimen fracture instantaneous pitch). Laser Raman spectroscopy Step ozone washing before and after the two sponge material without the formation of a new group, and did not change in its chemical structure. Part II: according to GB / T 16578-1996 standard test rinse before and after the film's load - displacement curve no significant change. The laser Raman spectroscopy Step ozone washing before and after the thin film material is not a new group is formed, there are no changes in its chemical structure. Part III: closed environment with time, the concentration of ozone water there will be a corresponding decrease, after 15 minutes, the concentration of ozone water were 0.32mg / L and 0.29mg / L. Conclusion: medical sponge polyurethane, polyvinyl alcohol, medical sponge and the semipermeable membrane can withstand the role of ozone, ozone negative pressure therapy system can be applied. The two sponge Comparative polyvinyl medical sponges superior polyurethane medical sponge. SN Company the Anshu properly semipermeable membrane before and after the ozone flushing, no significant change in tear resistance; ultra-high-concentration ozone water rinse after two hours, the pore diameter of the micropores increases. Ozone water in a sealed environment, and is decreased by the concentration with time after 15 minutes, still has a bactericidal ability.

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