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Objective: The main subject of observation of diabetes on high fat diet fat capsule with streptozotocin-induced diabetic rats lipid metabolism and adipose tissue in inflammatory chemokine plasminogen activator inhibitor 1 (PAI -1) expression levels to observe the role of its efficacy, to improve the scientific basis for clinical treatment.T2DM prevention and treatment for Chinese medicine to provide new ideas and methods, and in-depth study of micro-inflammation in the pathogenesis of T2DM and provide a theoretical and experimental basis.Methods: In this experiment, Wistar rats fed high fat diet for 4 weeks, fasting can not help but water 12h, intraperitoneal injection of 2% of the streptozotocin 30mg/kg-1, the normal group were injected with the 0.1mol.L-1 sterile citrate buffer. The successful model of the rats were randomly divided into model group, Diabetes lipid level group, rosiglitazone maleate, diabetes lipid level group by 3.6g/kg.d, rosiglitazone maleate by 4mg/kg.d gavage, the normal group and model group were given equal volume of distilled water. After 8 weeks with immunohistochemistry, protein levels were observed from the adipose tissue expression of PAI-1 situation.Results: 1, the experimental period, the model group, Diabetes fat Capsule group, maleate rosiglitazone group showed no significant difference in food intake, three sets of feeding were higher than the normal group (P <0.01 or P <0.05); one Diabetes fat Capsule group 13W intake lower than model group (P <0.05), compared with normal group was not statistically significant (P = 0.053).2, body weight comparison: test cycle, model, Diabetes fat Capsule group and rosiglitazone maleate body volume was significantly higher than normal rats (P <0.01); Diabetes fat Capsule Group 13W body weight was significantly lower than the first model group (P <0. 05), significantly lower than rosiglitazone maleate group (P <0. 05).3, C-reactive protein comparison: experimental period, the model group were significantly higher than the normal rat group (P <0.01), Diabetes fat group CRP levels were significantly lower than model group (P <0.05). Rosiglitazone maleate CRP group compared with the model group no significant decrease (P> 0.05). 4, glucose comparison: experimental period, the model group were significantly higher than the normal rat group (P <0.01), treatment group was significantly lower than model group (P <0.01), but higher than the normal group (P <0.05).5, blood lipids comparison: model group, CHO, TG, HDL, LDL levels were significantly increased compared with normal group, a significant difference (P <0.01), similar with the literature, Diabetes lipid level group CHO, TG, LDL decreased significantly , compared with model group, there were significant differences (P <0.01 or P <0.05), rosiglitazone maleate LDL decreased significantly compared with model group (P <0.01), and CHO, TG and between the model group no significant difference (P> 0.05), and CHO levels were significantly higher than the Diabetes fat Capsule group (P <0.01).Conclusion: The large number of experimental studies have demonstrated that type 2 diabetes is a chronic low-grade inflammatory disease, inflammation and further clarify its mechanism of action of type 2 diabetes type 2 diabetes can provide more effective diagnosis, prevention and treatment. In modern medical research, based on full use of cell biology, molecular biology technology and other modern research methods, combined with traditional Chinese medicine with modern advanced scientific means and methods, the active chemical components of Chinese herbal medicine, in-depth study of inflammation in diabetic medicine state intervention in adipose tissue in inflammatory pathways, improve the mechanism of insulin resistance, and ultimately achieve weight loss, hypoglycemic, lipid-lowering, the purpose of slowing the complications of diabetes. Road is long Come, prevention and control of diabetes is a long and winding road, the majority of medical workers still need further study and discussion. Diabetes fat capsule with glucose, lipid, weight loss, anti-inflammatory effect and improve the IR. Adipose tissue in model group was significantly higher PAI-1, the diabetes treatment lipid capsule, PAI-1 levels were significantly lower, suggesting that PAI-1 may be caused by obesity, an important pro-inflammatory factors in T2DM; Diabetes lipid levels adipose tissue capsule can reduce the level of inflammatory cytokines, suggesting that PAI-1 is a new target for treatment of T2DM. Diabetes fat capsule which of the specific inflammatory signaling pathways start leading IR form, and whether it can repair the inflammatory signaling pathway needs further study.
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