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Objective: To observe Huo Xiang Zheng Qi Soft Capsule treatment of functional dyspepsia (Functional dyspepsia, FD), TCM Dampness focal permit clinical efficacy and adverse reactions to further explore the TCM and treatment of functional dyspepsia. Methods: A randomized, double-blind, double-dummy, parallel-group test methods. Pursuant to the random number table, 130 patients were divided into two groups, the experimental group and control group 65 cases, the test group patients taking: Huo Xiang Zheng Qi Soft Capsule (0.45 g, Darren Hall, Tianjin Zhongxin Pharmaceutical pharmaceutical production) domperidone Analog tablets (10 mg); control group patients taking: domperidone (10 mg, Xian-Janssen Pharmaceutical Co., Ltd.) Huo Xiang Zheng Qi Soft Capsule analog drugs (0.45g), three times a day for 4 weeks. Before and after the medication to the patient symptom scores and 13C-octanoic acid solid gastric emptying test, not through X-ray marker method two gastric emptying detection of clinical efficacy of the evaluation Huo Xiang Zheng Qi Soft Capsule. And before and after the test were carried out on patients with adverse reactions check to about adverse drug reactions. Results: after four weeks of treatment, the experimental group off two cases in the control group off three cases are due to busy patients unable to take medication on time, and a return visit, has nothing to do with drug efficacy and adverse reactions. The effective number of cases that the test group of 63 cases, and the effective number of cases of the control group of 62 patients. Symptoms efficacy observed after treatment experimental group total effective rate was 95.24%, markedly effective rate of 49.21%; 83.87% of the total efficiency of the control group, markedly effective rate of 29.03%, the test group was significantly higher (x2 = 4.333, P = 0.037). Symptom score after four weeks treatment, the test group average total symptom score in significantly better than the control group (P = 0.003). The main symptoms of bloating, early satiety, loss of appetite test group than the control group, the average score was significantly lower (P lt; 0.05), sticky mouth / bad breath groups average credit was no significant difference (P = 0.364). Not through the X-ray markers determination of gastric emptying 2 groups of patients with pre-treatment gastric emptying was no significant difference (P GT; 0.05) After treatment group improved gastric emptying of 14, accounting for 22.22% of this group of patients; improved gastric emptying of the control group of 10 people, accounting for 16.13% of this group of patients, after treatment, the experimental group to improve the situation significantly higher than the 5-hour gastric emptying the control group (P lt; 0.05). 2 4.13C-bitterness solid gastric emptying test before treatment gastric emptying in patients with no significant difference (P gt; 0.05) After 4 weeks of treatment, the experimental group improved gastric emptying higher than that in the control group (P = 0.043). Conclusion: Huo Xiang Zheng Qi Soft Capsule can effectively relieve the symptoms of functional dyspepsia (wet resistance of coke syndrome) enhance gastric peristalsis, promote gastric emptying, adverse reactions, worthy of clinical application.
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