Dissertation > Excellent graduate degree dissertation topics show

Study on Theories and Experiments of the Background Correction for Non-Invasive Blood Glucose Sensing with Near-Infrared Spectroscopy

Author: GuZuoYu
Tutor: XuKeXin
School: Tianjin University
Course: Measuring Technology and Instruments
Keywords: Near-infrared diffuse reflectance spectroscopy Non-invasive measurement of blood glucose Background subtraction Reference wavelength point Background space projection Dimensional correlation
CLC: R446.1
Type: PhD thesis
Year: 2007
Downloads: 292
Quote: 6
Read: Download Dissertation

Abstract


Blood glucose concentrations near infrared non-invasive measurement of worldwide concern and has important practical significance issue, but the results of their research is not yet true clinical application. Is the main problem currently facing complex physiological background, resulting in a weak signal is difficult to effectively extract the sugar. This paper conducted a background subtraction methods of research, in order to eliminate the interference of physiological changes in the background, non-invasive blood glucose monitoring technology to improve effectiveness. Theoretical analysis and experimental verification skin diffuse reflectance spectroscopy feasibility of blood glucose concentration. Monte Carlo simulation method proved this paper, based on non-invasive blood glucose monitoring systems, limit detection accuracy up to 5.2mg/dl; In animal experiments, the first to achieve the skin and blood vessels spectrum while spectral acquisition, the results show that the diffuse skin Diffuse reflectance spectra and spectral vascular good correlation between, for the near-infrared diffuse reflectance spectroscopy non-invasive blood glucose monitoring technology provides the experimental feasibility of evidence. Background subtraction method for basic research. The paper first sample measurement from the system hardware and sugar concentration of both research and information unrelated to the main background noise signal distribution. Drift for the system interference, the use of \For the impact of changes in the sample characteristics, the use of similar background subtraction method, which effectively improved in vitro measurement accuracy of the glucose concentration, glucose and Intralipid-2% aqueous solution of glucose concentration were increased prediction accuracy of 25.9% and 40.1% respectively. Made reference wavelength background subtraction method. According to the reference wavelength light diffuse reflection point the glucose concentration insensitive to changes in characteristics of the detection signal of this wavelength as internal reference blood glucose measurements, thus eliminating the interference of physiological changes in background. In pure absorption medium and the turbid medium theory and experimental verification of the existence of a reference wavelength points, on this basis, the theoretical analysis based on a reference wavelength of background subtraction formula and used in in vitro experiments, albumin and intralipid-2 three-component % solution of glucose concentrations were increased prediction accuracy of 50.3% and 40.3%. Proposed background space projection of background subtraction method. To be analyzed by the spectral projection on the background signal wavelength conversion sensitive subspace spanned - background space background signal to inhibit glucose-specific signal extraction purposes. Two-dimensional correlation theory, from the system point of view of hardware and system analysis measuring conditions near infrared diffuse reflectance spectroscopy in non-invasive blood glucose measurement wavelength characteristics of the background signal, and learn from the net signal space spanned by the concept of complete background space and the corresponding definition of the algorithm. Application of this method makes two component sugars and intralipid-2% aqueous solution of glucose concentrations were increased prediction accuracy of 25.8% and 26.6%.

Related Dissertations

  1. Intelligent video detection technology based on the traffic lights control,TM923.5
  2. Liquid Crystal Containing Dihydrazide Groups: Synthesis and Two-Dimensional Correlation Spectroscopy Study,O631.3
  3. The Detection Discrimination and Processing of the Object Picture in Site Monitoring System,TP391.41
  4. Depth Profiling of Polymer Layered Composite Materials Using Rapid-and Step-scan Phase Modulation Fourier Transform Infrared Photoacoustic Spectroscopy,TB332
  5. Humanoid identify key technology research and implementation,TP391.41
  6. Research on Moving Objects Detection Algorithms in Security Monitoring System,TP391.41
  7. Research on Moving Object Detection and Tracking in Sequence Image,TP391.41
  8. Movement Goal Examination and Video Monitoring Software Development,TP391.41
  9. Research on Target Tracking Technology of Digital Monitoring System,TP391.41
  10. Multiple Targets Tracking in Traffic Image Sequences,TP391.41
  11. Analysis and Identification of Fritillaria by Using Infrared Spectroscopy Method,R284
  12. Low-contrast environments moving target detection technology,TP391.41
  13. Research on Moving Object Detectiona nd Shadow Removal in Video Sequcnce,TP391.41
  14. Video-based vehicle monitoring systems across the road violation,TP274
  15. Research and Implementation of Some Key Technique on Intelligent Monitoring System,TP277
  16. Quantification of Pathogeny Factors in Wind-hot and Hot-wetness Cold Caused by Exogenous Evils and Multidimentional Correlation Study,R254
  17. The vehicle occlusion detection algorithm,TP391.41
  18. Wavelet analysis in drug / explosive detection research,TP391.41
  19. Video Surveillance moving target detection method,TP277
  20. Moving Object for Visual Tracking,TP391.41
  21. Investigation on Detection and Segmetation of Moving Object in Video Sequences,TP391.41

CLC: > Medicine, health > Clinical > Diagnostics > Laboratory diagnosis > Biochemical testing, clinical testing
© 2012 www.DissertationTopic.Net  Mobile