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Localization of Epileptic Focus and Brain Functional Areas by Magnetic Source Imaging

Author: SunJiLin
Tutor: WuYuJin
School: Hebei Medical University
Course: Neurology
Keywords: Magnetoencephalography Magnetic source imaging Epilepsy Somatosensory evoked magnetic fields Listen to induce a magnetic field Language Dominant hemisphere
CLC: R742.104
Type: PhD thesis
Year: 2002
Downloads: 135
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Abstract

In China, the prevalence of epilepsy is approximately 3 ‰ ~ 6 ‰, and refractory epilepsy accounts for about 20%. As the use of antiepileptic drug therapy in refractory epilepsy, which seek partial surgical resection of the epileptic focus or gamma knife radiation therapy. However, the key to good effect is the precise positioning of the epileptic focus in and around the important functional brain energies. Due to inter-individual differences in the human body and brain tumors, the normal anatomy of the change, simply by CT and MRI to identify the central sulcus and some important cortical functional area is sometimes very difficult, and the possibility of deviation. Accurate positioning method for intracranial electrode. Intracranial electrodes, however, be checked for traumatic, increased operative time and the possibility of infection, increasing the patient's pain. Brath et al in 1982 for the first time magnetoencephalography (magnetoencephalography, MEG) for epileptic foci positioning MEG positioning of epileptic foci. Then use the single-channel device. Using a small array sensor system (7-channel or less number of channels) to identify epileptic interictal spikes, because the sensor is less need to move in different parts of the brain the Dewar's bucket to measure both time-consuming and can not be simultaneously recorded brain electrophysiological activity. Over the past decade, the development of multi-channel devices to accelerate the speed of the recorded data, to improve the positioning accuracy. MEG sensor allows simultaneous recording of up to 300 magnetoencephalography channels. The early 1990s, clinical application, the so-called magnetic source imaging (magnetic source imaging, MSI) is physiological activity recorded by the MEG EEG and magnetic resonance imaging MRI (magnetic resonance imaging, MRI, magnetic source imaging (magnetic source imaging, MSI) ) obtained by the anatomical structure superimposed images produced is non-traumatic brain function detection technology. Published with no domestic magnetic source imaging theory. This study MSI in the following aspects: (1) the MSI of the epileptic focus positioning; (2) MSI positioning of the primary somatosensory cortex; (3) MSI positioning of the primary somatosensory cortex of patients with intracranial tumors; (4) MSI The positioning of the primary auditory cortex; (5) MSI positioning of the language cortex. By the positioning of the epileptic focus and important functional areas of the brain, guiding brain surgeon to determine the preoperative surgical plan, resection of lesions to the greatest extent possible, while retaining the important functional areas, to improve the quality of life of patients. All contents and results are as follows: 1, magnetic source imaging study of the epileptic focus localization purposes: application of magnetic source imaging of epileptic focus localization, to study the value of magnetic source imaging in the localization of epileptic foci in epilepsy Chinese summary. : American production by 4D Neuroimaging 306 channel whole head biological magnetometer (a vector state ew 306-ch deleted el wholt-SCaleblomagnetorneter, MEG) of 19 cases of epilepsy the carbuncle patients (11 men and 8 women, age 3 to 52 years, an average of 24 years old) interictal epileptic focus positioning and synchronous 64 conductivity EEG is recorded. MRI scans using the U.S. company GE Signa. ST scanning system. MEG electrophysiological data obtained with MRI anatomical structure superimposed Results: 15 cases of interictal spikes measured magnetic source imaging (magnetic source imaging, MSI), including 8 patients with epilepsy source multifocal ( seven cases of two of stoves or two more people for a single lesion. 4 cases not detected spikes in epileptic patients detected in 15 cases, 3 cases of MR for the side of the prefrontal hippocampal sclerosis; 2 cases malacia: The remaining normal MRI in three cases of patients with hippocampal sclerosis, epilepsy source in the hippocampal sclerosis the ipsilateral Ying Ye; epileptic source in the bilateral frontal; epileptic source in hippocampal sclerosis the contralateral lateral fissure and the central ditch near the group of patients, 2 patients with clinical manifestations Ying lobe epilepsy symptoms, thinking normal MRI, MSI displayed two cases of epilepsy sources are located in the frontal lobe and are single lesion. 2 cases of patients with cerebral malacia one cases of epilepsy carbuncle source away from malacia patients with epilepsy carbuncle source is located around the brain malacia. therefore consider spikes epilepsy carbuncle does not necessarily around the malacia in three cases of acquired aphasia few fi song U-me even lCr Syfl lights Ome, than u patients, two cases spike wave discharges are mainly located in the left sylvian fissure area; cases spikes mainly in bilateral central sulcus and surrounding cortex and the right Ying on back, patients underwent bilateral central sulcus the the surrounding subcortical fiber transection postoperative aphasia symptoms improved significantly. therefore that the surrounding cortex and bilateral lateral fissure near the central sulcus cortex epilepsy source discharge can lead to Cardiff language this group of patients in eight cases of seizures as \characterized by the MEG epilepsy carbuncle source observed 8 patients, in addition to cases of epilepsy carbuncle source as a single stove, the rest of the patients the epilepsy source a wide range, independent of the source of epilepsy at least 2 to 3. 2 pounds derived shadow Jun on primary somatosensory cortex positioning research purposes: the application of magnetic source imaging to determine the location of the the cerebral primary somatosensory cortex Methods: 16 right-handed healthy subjects as a test object, including 8 males and 8 females, age range 20 to 48-year-old, on the subjects of bilateral wrist electrical stimulation of the median nerve, causing the dominant hand cortical excitability of primary sensory brain excitability of the brain primary sensory cortex generate weak magnetic field of extracranial American 4D Neuroimaging 306 channel full the the head type biological magnetometer (Vectorwew306-ch deleted el whole-scale blomagneto Vision ter, MEG), weak extracranial magnetic field measurements. magnetoencephalography check, the subjects underwent MRI examination using the device for the US-2 Chinese Abstract country GE the production of Signa.ST magnetic resonance system scan sequence for the SE sequence, sagittal TIWI will the MEG results superimposed onto MAt on, magnetic source imaging (MSI Results: All subjects were M20 crest (electric stimulation of the wrist about 20ms after median nerve somatosensory evoked magnetic fields) and M35 crest (electrical stimulation of wrist median nerve somatosensory evoked 35ms about the magnetic field only two cases of apparent M60 crest (electrical stimulation of the median nerve at wrist 60ms somatosensory evoked magnetic field M20 peak latency occurs around 20 stone disabilities l.lins, the M35-peak latency 32.4 Guests 2.gms. the same subjects M20 the crest and M35 crest, and other current dipole with MRI superimposed MSI ?

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