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Tripterygium glycosides transplantation immunosuppressive effects and pituitary cultured pituitary transplantation observation

Author: XuLin
Tutor: WangWeiJun;RenZuYuan;ZuoChongZheng
School: Peking Union Medical College , China
Course: Neurosurgery
Keywords: Tripterygium Medical Concorde Endocrine function Median eminence Organ transplant Hypothalamic Immunohistochemical staining Hormone levels Allogeneic
CLC: R651
Type: PhD thesis
Year: 1993
Downloads: 35
Quote: 0
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Abstract


Neuroendocrinological regulation is essential to human lifeThe pituitary plays an important role in the feedbackregulationg cycles of neuroendocrinological system inconnecting the central nervous system with peripheral targetglands and cells. Pituitary transplantation ( PT) is oftenemployed in basic and clinical medical researches.Immunological rejection is one of the key problems of PTResearchers have tried a few methods to weaken the rejectionreaction in PT. Up till now, no satisfactory method of thiskind has been searched out, therefore, further studies arenecessary.The effects of pituitary culture and T2 on PT were studied in this experiment. The rat6 were divided into 9 groups (A-Ⅰ):A, mormal control; B, sham-operated; C, hypophysectomized; D, newly taken pituitaries from the donors were transplanted heneath the median eminence of hypophysectomized recipients using the parapharyngeal approach; E, PT wa6 done as group D , T2 had been given 50mg/kg/day p. o for 7 days from 24 hours before the operation , then, 30mg/kg/day for 3 weeks; F, PT was done as group D, CyA had been given 10mg/kg/day p. o for 7 days from 24 hours before the operation, then, 5mg/kg/day for

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