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The Relationship between the -58T/C Polymorphism of the Bradykinin β2 Receptor Gene, the G894T Polymorphism of the Endothelial Nitric Oxide Synthase, the C825T Polymorphism of G Protein β3 Subunit and Antihypertensive Response to ACE Inhibitor

Author: ChenGaiLing
Tutor: LiuGuoZhang;DangAiMin;WuHaiYing
School: Peking Union Medical College , China
Course: Cardiovascular within science
Keywords: Antihypertensive efficacy Gene polymorphism Hypertensive patients Medical Nitric oxide synthase Genotyped Systolic blood pressure Gene promoter Allele Diastolic blood pressure
CLC: R544.1
Type: PhD thesis
Year: 2004
Downloads: 105
Quote: 0
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Abstract


Essential hypertension is a kind of multiple genetic disease,which is the independent risk factors of coronary heart disease, stroke, left ventricular hypertrophy, acute myocardial infarction. Several studies showed only 50% of the patients benefit from antihypertensive drugs. Individuals may respond differently to the same antihypertensive medication. It has been suspected that interindividual variation on the efficacy may be influenced by genetic factors. It is an useful strategy to stduy candidate genes of antihypertensive drugs efficacy.It is well known that bradykinin β2 receptor,G protein β3 subunit, endothelial nitric oxide synthase play the important role in blood pressure regulation.The aim of present study is to investigate the — 58T/C polymorphism of the bradykinin β2 receptor gene (BDKRB2) , the G894T polymorphism of the endothelial nitric oxide synthase (eNOS) and the C825T polymorphism of G protein β3 subunit in Chinese essential hypertensive patients and the relationship between genotype and antihypertensive response to ACE inhibitor.

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
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