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Studies on Chemome and Metabolome of Gardenia Jasminoides Ellis by Multiple-dimensional Chromatography-electrospray Ionization Mass Spectrometry

Author: ZhouZuoZuo
Tutor: WuYuTian;FanGuoRong
School: Second Military Medical University
Course: Pharmaceutical Analysis
Keywords: Gardenia Iridoid terpene glycosides Dimensional liquid chromatography High - speed countercurrent chromatography Fingerprints of Metabolic spectrum Pharmacokinetics Effective parts
CLC: R284
Type: PhD thesis
Year: 2007
Downloads: 646
Quote: 0
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The systematic and comprehensive study on active components from Gardeniajasminoides Ellis. was carried out. Ten iridoid glycosides were obtained bymultiple-dimensional chromatography, and the preparation protocol of the active componentsgroup had also been established. Moreover, the rapid isolation platforms of some compoundsby on-line HPLC-HPLC column switch technique and on-line purity monitoringHSCCC-HPLC-DAD system had been established. Chemical fingerprint and metabolicfingerprint analysis of Gardenia jasminoides Ellis. by HPLC-DAD-ESI-MS technique wasestablished and the preclinical pharmacokinetics of the iridoid glycosides was also studied.

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