Dissertation > Excellent graduate degree dissertation topics show

Studies on Copper and Bismuth Catalyzed Domino Reaction for Synthesis of Polycyclic Aromatic Hydrocarbons (PAHs)

Author: WangXiangChuan
Tutor: LiangYongMin
School: Lanzhou University
Course: Organic Chemistry
Keywords: copper·bismuth·domino·polycyclic aromatic hydrocarbons EnyneCycloisomerization Multicomponent reactions (MCRs)
CLC: O621.36
Type: PhD thesis
Year: 2012
Downloads: 79
Quote: 0
Read: Download Dissertation

Abstract


Metal-catalyzed cycloisomerization reactions of 1,n-enynes have appeared as conceptually and chemically highly attractive processes as they contribute to the highly demanded search for atom economy and allow the discovery of new reactions. Since the pioneering studies with palladium by the research group of Barry Trost in the mid-1980s, several other metals have been identified as excellent catalysts for the rearrangement of enyne skeletons. Moreover, the behavior of 1,n-enynes may be influenced by other functional groups such as alcohols, aldehydes, ethers, alkenes, or alkynes, thus enhancing the molecular complexity of the synthesized products. Apart from the intrinsic rearrangements of 1,n-enynes, several tandem reactions incorporating intramolecular trapping agents or intermolecular partners have been discovered.Recent years, we also have some studies on copper and bismuth catalyzed domino cycloisomerization reactions of 1,n-enynes for synthesis of polycyclic aromatic hydrocarbons (PAHs), as shown in the following 3 parts:PartⅠ:We developed a novel intermolecular condensation reaction of 1,3,5-triarylenynols catalysed by copper, which involved dimerization fragmentation and [4+2] cycloaddition-dehydrogenation. This reaction is a straightforward method for the synthesis of highly conjugated aromatic 1H-cyclopenta[b]naphthalenes. These products are extremely useful in material chemistry.Part 2:We developed a straightforward method for the synthesis of multisubstituted fluorene with (Z)-2-en-4-yn acetates and ethynylbenzene catalyzed by BiBr3 via domino reaction, which involved intermolecular, intramolecular electrophilic addition and cycloisomerization aromatization. Variation of substituted groups was proven possible and this reaction can proceed smoothly in moderate to good yields.Part 3:A new and efficient synthesis of substituted indene has been achieved via Copper (Ⅰ)-catalyzed domino three-components coupling and cyclization reaction inmoderate to good yield

Related Dissertations

  1. Investigation on the Asymmetric Transfer Hydrogenation of β-Oxosulfonamides and the Organocatalytic Synthesis of 5-Hydroxypyrazolidines,O621.36
  2. Study on the Ytterbium Chloride Catalyzed Synthesis of Pyridones and the Synthesis and Application of D-Mannitol Derivative Ligands,O621.36
  3. Asymmetric Reduction of Prochiral Carbonyl Compounds by Recombinant Oxidoreductases Expressed in Escherichia Coli,O621.36
  4. Immobilization of β-D-glucuronidase on PILC and Biosynthesis of GAMG,O621.36
  5. Copper-Catalyzed Synthesis of Disubstituted Imidazolones,O621.36
  6. Copper-Catalyzed Synthesis of Bicyclic Pyrimidinones,O621.36
  7. Vapor-Phase Synthesis of 1-Phenylazepane from Aniline and 1,6-Hexanediol Over NiO/SiO2-Al2O3 and NiO-CoO/SiO2-Al2O3 Catalyst,O621.36
  8. Nickel Catalyzed Synthesis of Highly Functionalized Pyrimidine Heterocycles,O621.36
  9. D-tartaric acid modified RaneyNi catalytic asymmetric hydrogenation of synthetic borneol camphor,O621.36
  10. CuI-Catalyzed Tandem Carbomagnesiation/Nucleophilic Addition of Grignard Reagents and Acetylenic Ketones,O621.36
  11. Yttrium-doped calcined hydrotalcite acetone Preparation and catalytic synthesis of isophorone copper,O621.36
  12. Investigations into the Electrocatalytic Synthesis and Electron Transfer Mechanism of the Diiron Subsite of [FeFe]-Hydrongenase Model Complex,O621.36
  13. 1,2,4-triazol-5-ylidene-Palladium Complexes: Synthesis, Structure and Their Application in the Organic Reactions,O621.36
  14. Researches on Phosphine-Catalyzed (4+n) Cycloaddition Reactions,O621.36
  15. Immobilized Candida Antarctica B Lipase Catalyzed Synthesis of Medium Chain Diacyglycerol and Sucrose Ester,O621.36
  16. Synthesis of Acridine and 2,3-dihydro-furans Derivatives Catalyzed by Iron or Zinc,O621.36
  17. Lewis Acid Catalyzed Organic Reactions in Organic Synthesis,O621.36
  18. Synthesis of Polysubstituted Naphthalene Derivatives by the Pyrrolidine Catalyzed Domino Reaction,O621.36
  19. Green Chemistry Synthesis of several types of organic carbon and nitrogen (oxygen ) compounds,O621.36
  20. Synthesise of Cyclopentadecanolide from Methyl 15-Hydroxy-Pentadecanate by Lipase and Dynamics During Two Systems,O621.36
  21. Transition-metal Catalyzed Reactions of Enynes and Study Toward Synthesis of Indole Alkaloids: Minfiensine and Phalarine,O621.36

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Synthetic organic chemistry > Heavy organic synthesis or catalytic organic synthesis
© 2012 www.DissertationTopic.Net  Mobile