|
Glucose -responsive polymers are of concern because they have two potential applications of glucose sensing and insulin release . Phenylboronic acid and its derivatives or a sugar -responsive material. Phenylboronic acid complexation with a polyhydroxy compound , and therefore can be of polyhydroxy substances in the body identification function for autonomic delivery system or regulate certain life activities . Polyethylene glycol (PEG) , its non-toxic , non-irritating, good solubility in water , and good compatibility with many organic component and the raw materials were selected for this experiment , and also serves as an ideal hydrophilic fragment is widely used. This thesis successfully synthesized in MPEG as a hydrophilic segment to phenylboronic acid ester PPBDEMA for the hydrophobic segments of the amphiphilic sugar -responsive polymer . The objectives of this study are as follows: 1, 1,1,1 - trimethylolpropane and phenylboronic acid as raw materials , with propylene chloride modified successfully synthesized a novel benzene boronic acid ester monomer PBDEMA And MPEGBr macroinitiator to PBDEMA the series having a different length of the hydrophobic segments of the amphiphilic polymer is MPEG - block - PPBDEMA , as monomers, obtained by ATRP polymerization . Amphiphilic block copolymers by solvent evaporation method white assembly , self- assembled nanoparticle system characterized by means of TEM, DLS , and CMC nanoparticles morphology , particle size distribution and size , as well as the ability to form micelles . The results showed that the distribution of particle size of the nanospheres formed generally are less than 100 nm , and the scope of the CMC 49 to 115 mg / L . 3, Nile Red and FITC-insulin as a model drug of the fluorescent molecules , the amphiphilic polymers the MPEG- , block- PPBDEMA as a drug carrier, wrapping test sugar in response to the release behavior . The results show that under physiological conditions ( 37 ° C , pH 7.4 ) can occur with sugar response and release behavior, and fructose than the glucose - responsive sensor . In addition , through the IR validation sugar response structure changes in particle size by DLS test before and after the response of its sugar increased from 30 nm to 170nm , which are further evidence of its sugar response to the occurrence of the release behavior .
|