Dissertation > Excellent graduate degree dissertation topics show

Mechanisms of Cytotoxicity on HepG2Cells Induced by Tetrabromobisphenol A(TBBPA) and Its Dose-response Assessment

Author: XiangMingDeng
Tutor: YuYunJiang
School: Chinese Academy of Environmental Science
Course: Environmental Science
Keywords: TBBPA Cytotoxicity Oxidative stress Apoptosis Dose-response
CLC: R114
Type: Master's thesis
Year: 2012
Downloads: 101
Quote: 0
Read: Download Dissertation

Abstract


LOAEL, BMDL10and BMD10for TBBPA were10,15,9.45and10.34μM respectively.Based on the results of this study, the following conclusions could be made:(1) TBBPA could cause cell death in HepG2cells.(2) TBBPA could generate oxidative stress in HepG2cells.(3) The cytotoxicity of TBBPA on HepG2cells may be caused by oxidative stress.(4) TBBPA could induce apoptosis in HepG2cells.(5) The value of BMDL10for TBBPA were9.45μM, which selected the inhibition rate after24h exposure as endpoint.

Related Dissertations

  1. The Study on Cryopreservation and Mechanism of Freezing Injury on the Spermatozoa of Coelomactra Antiquate,S968.3
  2. The Anti-tumor Effect of CADPE and Inducing Apoptosis in Human Gastric Cancer Cells,R735.2
  3. Cloth and β- elemene combined administration of anti-tumor effect and mechanism of celecoxib,R96
  4. Design, Synthesis and Biological Evaluation of Novel Podophyllotoxin Derivatives as Antitumor Agents,R284
  5. TRAIL in the regulation of tumor invasion CD4 ~ CD25 ~ Treg,R730.2
  6. The Study of Lead Exposure on Cyprinus Carpio Ovary Epithelial Cells,X174
  7. Synthesis and properties of new functionalized graphene oxide drug carriers,TQ460.4
  8. Effects of Diclazuril on G3PDH in Second-generation Merozoites of Eimeria Tenella,S858.31
  9. The Effects and Preliminary Study of PCV2 on Ca2+ Signal in Lymphocytes of Piglets,S858.28
  10. Effects of Angiogenic Factor on Follicular Angiogenesis and Development in Sexual Maturity Mice,S852.2
  11. Expression of β-Catenin in Pig’s Ovary and the Effect of β-Catenin on Porcine Granulosa Cells Apotosis and Steroidogenesis Related Enzyme,S828
  12. Induced Combination Apoptosis by FB1 and AFB1 in Vero Cell,S856.9
  13. The Apoptosis Mechanism Induced by Aflatoxin B1 and Deoxynivalenol in Primary Hepatocyte of Cyprinus Carpio,S856.9
  14. Effects of BMPR-IB Gene Silencing by Small Interfering RNA on Apoptosis of Porcine Pollicular Granulosa Cells and Ecpression of BMP Pathy-Way-Ralted Genes,S828
  15. The Effects of Don on Proliferation, Differentiation, and Apoptosis of Chondrocytes in Chicken,S858.31
  16. The Effect of Foxol on Apoptosis of Mouse Granule Cells,S865.13
  17. Study of Melittin on Tumor Inhibition and Part of Mechanism of Human Hepatocellular Carcinoma HepG-2 Xenograft in Nude Mice,R735.7
  18. The Investigation on the Renal Injury and Effects on Oxidative Stress of Guinea Pigs Induced by Trichloroethylene,R363
  19. The Protective Effect of Rat Myocardial Ischemia/reperfusion Injury Following Bone Marrow Mesenchymal Stem Cell Pretransplantation for 1 Week,R542.22
  20. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8
  21. The Effects of (180F-FDG on the Apoptosis of Eca-109 Esophageal Cancer Cell Line,R735.1

CLC: > Medicine, health > Preventive Medicine,Health > Health - basic science > Health Toxicology
© 2012 www.DissertationTopic.Net  Mobile