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Effects of Caffeic Acid on Depressive Behavior in Cums Rats

Author: MaQingYang
Tutor: YangJunQing
School: Chongqing Medical University
Course: Pharmacology
Keywords: caffeic acid 5-LO CUMS hippocampus depression
CLC: R285.5
Type: Master's thesis
Year: 2012
Downloads: 70
Quote: 0
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Abstract


Objective:To investigate the effect of caffeic acid on depressive behavior in chronic unpredictable mild stress (CUMS) rat and preliminary explore its mechanism.Methods:Chronic unpredictable mild stress was used to establish the rat model of depression. caffeic acid (10,30and50mg·kg-1) and setraline (5mg.kg-1) was ig administered after stress procedure for21d. Open-field test, forced swimming test and elevated plus-maze test was used to evaluate the depressive behaviors of rat. The superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in hippocampus of rat were determined by biochemisty enzymology. Interleukin-1beta (IL-1β), interleukin-6(IL-6) and tumour necrosis factor alpha (TNF-α) concentration in rat hippocampus were detected by ELISA. The expression of brain derived neurophic factor (BDNF), synaptophysin (SYP), postsynaptic density protein-95(PSD-95) and5-hydroxytryptamine receptor1A (5-HT1A) in hippocampus were determined by the method of immunohistochemisty.Results:Compared with that of normal control group, treatment of CUMS caused a significant increase of latent time, the percentage of immobility (PI) and open-arms retention time (OT), while a decrease of crossing time, rearing time and close-arms retention time (CT) of rats. Hippocampal neurons of model rat showed obviously karyopycnosis. The MDA content and the expression of IL-1β, IL-6and TNF-α significantly increase, and the SOD activity and expression of BDNF, SYP, PSD-95and5-HT1A decreased in model group compared with control group. Administration of caffeic acid obviously decreased the latent time, PI and OT, and increased the crossing time and CT compared with model group. caffeic acid could prevent the hippocampal neurons damage from CUMS. The SOD activity and expression of BDNF, SYP, PSD-95and5-HT1A signifificantly increased while the MDA content and the expression of IL-1β, IL-6and TNF-α significantly decreased in caffeic acid-treated group.Conclusion:The results suggested that caffeic acid have an effect on depressive behavior induced by CUMS in rats. The inhibition of5-LO activity, the antioxidate stress and anti-inflamation may be involved in the protective mechanism of caffeic acid.

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