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The Original Clinical Features of Diabetic Cerebral Infarction and the Impact of Glycosylated Hemoglobin and Serum Uric Acidon the Theraputic Effect of This Disease

Author: YuanYingKui
Tutor: ZhuHongCan; MiaoWang
School: Zhengzhou University
Course: Neurology
Keywords: cerebral infarction diabetes clinical features theraputic edffect glycated hemoglobin blood uric acid
CLC: R587.2
Type: Master's thesis
Year: 2012
Downloads: 6
Quote: 0
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Abstract


Objective:To compare the initial clinical features of diabetic cerebral infarction and non-diabetic cerebral infarction, to compare the total theraputic effect of the two groups, and the impact of glycosylated hemoglobin and serum uric acid on the theraputic effect of diabetic cerebral infarction.Methods:168cases of the hospitalized patients with acute cerebral ischemia for the first time was continuously collected, which was diveded into group of diabetic cerebral infarction and group of non-diabetic cerebral infarction according to combining with or without diabetes mellitus. The former group was further divided into three subgroups as to glycosylated hemoglobin (HbA1c) level:Mild (HbA1c<6.5,25cases), Moderate (6.5≤HbAl≤9.0L,16cases) and Severe (HbAlc>9.0,17cases), which also was diveded into the other two subgroups according to blood uric acid: High (25cases) and normal (33cases). Compare the basic material, blood pressure, blood lipid, blood uric acid, and especially the initial symptoms and signs such as conscious state, limb numness, paralysis and positive pathological sign. After standard treatment in hospital, theraputic effect of each groups and subgroups was assessed according to the theraputic effect standard by the fourth national conference of cerebrovascular disease. The whole theraputic effect between diabetic cerebral ischemia group and non-diabetic cerebral ischemia group, the theraputic effect among three HbA1c subgroups and between blood uric acid subgroups was then respectively compared.Results:(1) There was no significant difference of age, sex composition and other basic materials between diabetic cerebral infarction group and non-diabetic cerebral infarction group (P>0.05).(2) Diabetic cerebral infarction group and non-diabetic cerebral infarction group comparison:the indicators such as blood pressure, blood sugar, blood lipids, blood uric acid, in addition to FPG outside only the T/H (Lipid rate:TC/HDL-C) diabetic braininfarction group was higher than statistically significant difference (P<0.05). The rest of the two groups was no significant difference.(3) The occurrence of paralysis, aphasia and positive pathological sign was significantly lower (P<0.05), and that of limb numbness was significantly higher in diabetic cerebral infarction group than in non-diabetic cerebral infarction group (P<0.05), while that of conscious disorder, dizziness, headache didn’t have significant difference between the two groups.(4) The whole theraputic effect of diabetic cerebral ischemia group was signicantly worse than non-diabetic cerebral ischemia group (P<0.001).(5) The theraputic effect was significantly different among three HbAlc subgroups in diabetic cerebral infarction group (P<0.001), which of mild subgroup was significantly better than moderate subgroup (P<0.001)and severe subgroup (P<0.001), and which of moderate subgroup was better than severe subgroup (P=0.041).(6) The theraputic effect of high blood uric acid subgroup was significantly worse than normal uric acid subgroup in diabetic cerebral infarction group (P<0.05).Conclusion:The paralysis, aphasia and positive pathological sign was less common as initial symptoms and signs, while the theraputic effect was significantly worse in cases of diabetic cerebral infarction. High HbA1c level and hyperuricemia is perhaps potential impact factors of worse theraputic effect of diabetic cerebral infarction.

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CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetic coma and other complications
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