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The Clinical Significance of Transcutaneous Oxygen Pressure Testing in Type2Diabetes Peripheral Neuropathy

Author: XuChiTian
Tutor: HuZhiTao
School: Anhui Medical University,
Course: Neurology
Keywords: Diabetic peripheral neuropathy transcutaneous oxygen pressure EMG
CLC: R587.2
Type: Master's thesis
Year: 2013
Downloads: 7
Quote: 0
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Abstract


Objective The local microcirculation dysfunction of the vascular lesions caused bynourished peripheral nerve may be one of important pathological mechanisms ofdiabetic peripheral neuropathy. In this article, we detect the lower limb localtranscutaneous oxygen pressure （TcPO2） of patients with type2diabetes to get to knowlocal microcirculation dysfunction, then to investigate the relationship between the levelof transcutaneous oxygen pressure （TcPO2） in dorsalis pedis and the occurrence ofperipheral neuropathy in patients with type2diabetic. Provide theoretical basis for theclinical diagnosis and treatment of peripheral neuropathy in type2diabetes.Methods Collected145cases of hospitalized patients with type2diabetes, Statisticsgender, age, course of the disease, height, weight, blood sugar, glycosylated hemoglobinlevels, blood lipid levels, etc. Find out the related influence factors of type2diabetesperipheral neuropathy. According to the EMG and Neurological examination results,145cases of type2diabetic were divided into two groups:96patients with peripheralneuropathy （DPN） and49cases without neuropathy （NDPN）.With the asking way,96patients with nerve （DPN） can divide again without feeling was abnormal in30ofneuropathy （DPNA group） and neuropathy feel abnormal in66（DPNB group）. Inaddition,40normal participants were served as the control group（Con）. The TcPO2indorsalis pedis were detected in all subjects by TCM-400, and the monitoring results andthe abnormality rates were compared among groups. Results The abnormal rate of TcPO2in the group of diabetic peripheral neuropathyparaesthesia （group DPNB） were90.9％, diabetic peripheral neuropathy in patients withno clinical paraesthesia （group DPNA） were56.7％,Type2diabetes patients withoutPeripheral neuropathy （group NDPN） were34％,and normal participants（group Con）were12.5％. The knee and foot dorsum TcPO2values were significantly lower than thehealthy control group （group Con） whether there diabetes patients are peripheralneuropathy or not, and the difference was statistically significant （P <0.05）;the dorsalispedis TcPO2values of Diabetic peripheral neuropathy （group DPN） is lower than thediabetes without neuropathy group （group NDPN）,and the difference was statisticallysignificant （P <0.05）; The TcPO2value of knee between diabetic peripheral neuropathy（group DPNA） and diabetes peripheral neuropathy group （group NDPN）, there was nostatistical difference （P>0.05）;then the knee and foot dorsum TcPO2values of diabeticperipheral neuropathy with paresthesia group （group DPNB） is lower than diabeticperipheral neuropathy no paresthesia group （group DPNA）,the difference wasstatistically significant （P <0.05）.Conclusion Patients with lower limb local microcirculation disorders exist in Type2diabetes mellitus and peripheral neuropathy, Local transcutaneous oxygen pressure（TcPO2） measurement has been a certain clinical significance in early diagnosis ofdiabetic peripheral neuropathy as a simple, noninvasive clinical and economic latedetection method, at the same time, there may be a certain guiding value for theprevention and treatment of DPN.

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