Dissertation > Excellent graduate degree dissertation topics show

Addition Criminal Artery Stenosis to ABCD2Score to Identify Patients at Early Stroke Risk after Transient Ischemic Attack

Author: ChengZhengPing
Tutor: WuJie
School: Jilin University
Course: Clinical
Keywords: Transient ischemic attack cerebral infarction ABCD2score criminalartery stenosis
CLC: R743.31
Type: Master's thesis
Year: 2012
Downloads: 69
Quote: 0
Read: Download Dissertation

Abstract


Background Transient ischemic attack (TIA) is one of the mainprecursors of cerebral infarction, with third of the TIA patients developing tocerebral infarction. According to the high stroke rate after TIA, it’s veryimportant to provide clinic assessment timely and accurately. Since the21stcentury, California score, ABCD score and ABCD2score have been developedwith the purpose of predicting short-term risk of stroke after TIA. ABCD2scoring system have been extensively used in recent years, however, duing tolack of imaging in this scoring system, it needs to be further improvement. Inthis study, we added criminal artery stenosis to ABCD2score to identifypatients at early stroke risk after transient ischemic attack.Materials and Methods From Sept.2010to Apri.2012,99hospitalizedTIA patients were involved in the study, which were collected All patients werescanned with brain magnetic resonance imaging (including DWI), and CTAexamination in evaluating brain infarction. According to the criminal arterystenosis rate, the patients were divided into two groups:<50%group and≥50%group. According to the scoring system of ABCD2combined withcriminal artery stenosis, the patients were separated into low risk group, midrisk group and high risk group. The incidence of stroke within7days afteronset of TIA were assessed and compared predictive value among the fourscoring systems. The risk factors of stroke after TIA were evaluated by logisticregression mode1.Result9.30%patients had a stroke within7days in low risk group (score0-3),29.79%had a stroke in mid risk group(score4-6), and66.67%in highrisk group(score7-9).The incidence of cerebral infarction was higher in high risk group compared with other two groups within7days after TIA (P<0.01).By contrast, the mid risk group remained associated with an increased risk ofstroke, although there was no significant difference in stroke within7days afterTIA between low risk group and mid risk group (P>0.05). Logistic regressionmodels showed that: patients with criminal artery stenosis≥50%werepredicted stroke risk within7days(OR=3.565,95%CI1.397~9.098, P<0.01),unilateral weakness (OR=4.560,95%CI1.552~13.401, P<0.01). By contrast, inpredicting the early risk with other factors after TIA, althouth there was nostatistically significance (P>0.05), there was associated with an increased riskof stroke.The stroke risk after TIA in7days were predicted: the area under thecurve of the scoring system of ABCD2combined with criminal artery stenosis,ABCD2score,ABCD score and California score were0.728,0.683,0.665,0.634.Conclusions The incidence of cerebral infarction within7days after TIAwere higher in high risk group compared with other two groups. The criminalartery stenosis≥50%and unilateral weakness were independent stroke riskfactors after TIA.The assessment value of the scoring system of ABCD2combined with criminal artery stenosis is evidently superior to others.

Related Dissertations

  1. Preliminary Studies on Peptidomics and Metabonomics of Cerebral Infarction with Blood Stasis Syndrome,R277.7
  2. Risk Factor Analysis in Leukoaraiosis Patients with Cerebral Infarction,R743.3
  3. Stroke Risk Predicti after Transient Ischemic Attack with ABCD2+MES Score,R743.3
  4. The Relationship of Serum Adiponectin、Nitric Oxide Synthase and Carotid Atherosclerosis in Patients with Acute Cerebral Infarction,R743.33
  5. The Clinical Study on Relationship between Plasma Homocysteine Levels and Recurrent Cerebral Infarction,R743.3
  6. The Effect of Berberine Hydrochloride on the Levels of Serum CRP and Complement C3, C4 in Patients with Acute Cerebral Infarction,R743.3
  7. Clinical Research on Cognitive Event-related Potential N300 in Acute Cerebral Infarction,R749.1
  8. Berberine on serum levels of superoxide dismutase and malondialdehyde levels in,R743.33
  9. A Study of Plasma Levels of ADMA and Its Role in Acute Cerebral Infarction Associated with Type Ii Diabetes,R743.33
  10. Association of ABCA1 Gene Polymorphism and Risk Factors with Cerebral Infarction,R743.33
  11. Risk Factors Related to Hemorrhagic Transformation′s Patients with Acute Cerebral Infarctions,R743.33
  12. The Clinical Features and CRP Gene Polymorphism of Cerebral Infarction Disease,R743.33
  13. Analysis of Clinical Characteristics in Young Patients with Acute Cerebral Infarction,R743.3
  14. Study of Image Lesion Patterns and Collateral Compensation to Cerebral Infarction Patients with the System of Ipsilateral Internal Carotid Artery Stenosis or Occlusion,R743.3
  15. Clinical Analyses of 148 Cases of Cerebral Infarction in Young Adults,R743.3
  16. A Related Clinical Study of Transient Ischemic Attack Developing into Cerebral Infarction,R743.3
  17. Relationship between the level of serum CXCL16 in patients with acute cerebral infarction and stroke subtypes,R743.33
  18. The Application Value of ABCD2 Score Uniting DSA to Predict the Recently Stroke Risk after Transient Infarction Attack,R743.3
  19. Study of Relationship between Infarction Distribution Patter in Diffusion-weighted Imaging and Stenosis of Arteries Supplied in Middle Cerebral Artery Territory,R743.33
  20. The Applied Value of MR Susceptibility Weighted Imaging in the Diagnosis of Hemorrhagic Cerebral Infarction,R743.3
  21. The Application Value of Susceptibility-weighted Imaging in Hemorrhagic Transformation of Cerebral Infarction,R743.33

CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke) > Transient ischemic
© 2012 www.DissertationTopic.Net  Mobile