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Expression and Clinical Significance of hMLH-1and hMSH-2in Han and Uygar in Xinjiang Area of Sporadic Colorectal Tumors

Author: YuJing
Tutor: ZhaoFeng
School: Xinjiang Medical University
Course: Pathology and Pathophysiology
Keywords: Sporadic colorectal carcinoma hMLH-1 hMSH-2
CLC: R735.3
Type: Master's thesis
Year: 2013
Downloads: 2
Quote: 0
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Abstract


Objective: To investigate the clinical significance of hMLH-1and hMSH-2in Hanand Uygur in Xinjiang area of sporadic colorectal carcinoma (SCC) and normal colorectalmucosa (NCM). Methods: Immunohistochemistry method is adopted to detect themanifestations of hMLH-1、hMSH-2in sporadic colorectal carcinoma for42cases ofUygur and175cases of Han women and64cases with NCM of Uygur and Han ascontrast group. Results:1. Patients of Han and Urgur nationalities in the study were80.6%and19.4%, respectively.2. The mean age of Uygur and Han patients were53.1%and62.4%, respecticely. There was a highly significant correlation.3. The negative rate ofhMLH-1in sporadic colorectal carcinoma and NCM between Uygur and Han wererespectively57.1%,40%,0. The negative rate of hMSH-2in sporadic colorectalcarcinoma and NCM between Uygur and Han were respectively33.3%,33.1%,0. Thereexists marked gap in the negative rates of hMLH-1in SCC between Han and Uygurpatients(P＜0.05). There was no significance in the negative rate of hMSH-2in Han andUygur patients.4. The negative rate of hMLH-1and hMSH-2in Han SCC patients wererelated to location and degree of differentiation(P＜0.05). The negative rate of hMLH-1and hMSH-2in Uygur SCC patients were related to degree of differentiation(P＜0.05).Conclusion: hMLH-1and hMSH-2have the marked positive rates between Uygursporadic colorectal carcinoma tissue and normal colorectal mucosa. The manifestations ofhMLH-1in sporadic colorectal carcinoma tissue among Uygur patients in Xinjiangresemble to those of Han patients. The mean age of Uygur SCC patients was younger thanHan. Combined detection of hMLH1and hMSH2proteins may be used for judging theseverity and prognosis of sporadic colorectal cancer, which helps improve patients’treatment program and rationalize their choices

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms
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