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An Experimental Study on Photon Counting Based Lock-In Detection System for Diffuse Light
Author: WangZhiChao
Tutor: ZhaoHuiJuan
School: Tianjin University
Course: Biomedical Engineering
Keywords: Multi-wavelength continuous wave diffuse light detection photon counting lock-in detection FPGA
CLC: R318.51
Type: Master's thesis
Year: 2012
Downloads: 9
Quote: 0
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Abstract
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Continuous Wave Diffuse Optical Imaging (CW DOI) can achieve organ level detection of human information and has the advantages of non-invasive, non-ionize, high time resolution and continuous dynamic function. CW DOI need the measurement of the surface distribution of the output photon flow inspired by more than one driving source, which means that source coding is necessary. The most currently used source coding in DOI is time-division multiplexing (TDM) technology, which utilizes the optical switch to switch light into optical fiber of different locations. However, in case of large amounts of the source locations, the measurement time will become too long to capture the dynamic changes in real-time. In this paper, a frequency division multiplexing source coding technology is developed to reduce the measurement time and to improve the time resolution.The Implemented system is comprised of two laser diode sources, a wavelength division multiplexer, a photon counting detector, FPGA based digital lock-in detection circuit, communication and digital-to-analog convert hardware as well as host computer based Labview program. However, when applied to practical diffuse light measurement experiment, several problems had been found concerning the accuracy and stability of the system performance, such as a relatively high dark noise, poor signal to noise ratio, slow data transfer rate, etc.For each of the above-mentioned problems, this paper made an analysis, proposed a solution as well as carried out a verification experiment. To deal with the dark noise and signal-to-noise-rate issue, the effect of parameter configuration on system performance had been studied. To cope with the gross errors emerging in measurements, impedance matching was adopted between the photon detector and FPGA I/O pin; besides, the input pulse to FPGA was preprocessed before it was used as trigger signal. For data transfer rate issue, the square root calculation was transplanted from host computer into FPGA so as to reduce the amount of data needed to transfer.Finally, experiments have been carried out to verify performance parameters the improved system can achieve. Results have shown that the measured value was consistent with the actual light intensity, with the maximum relative error of 7.32%; besides, the measurements of each channel within 16~30mm range of source-detector distance consistent with analytical results, with the maximum relative error of 17%.
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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > Other branches of biomedical engineering > Light,laser biomedical
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