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Preparation and Characterization of Injectable Polyphosphazene/Gelatin Composite Hydrogel

Author: CaoXiaoYan
Tutor: CaiQing
School: Beijing University of Chemical Technology
Course: Materials Science and Engineering
Keywords: Injectable Hydrogels Polyphosphazene Gelatin Biomineralization
CLC: R318.08
Type: Master's thesis
Year: 2011
Downloads: 41
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Abstract


The injectable hydrogel bracket due to its good biocompatibility, biodegradability and well organized affinity is widely used in tissue engineering and bio-pharmaceuticals. Two paths, this thesis a class the injectable POLYPHOSPHAZENE / gelatin composite hydrogel scaffold, to be adopted by the functional side groups polyphosphazene instead of small molecular cross-linking agent such as glutaraldehyde, to chemical crosslinking gelatin, better biocompatibility in the physiological environment more stable synthetic / natural polymer composite hydrogel material. The path will hydroxybenzaldehyde (PHBA) grafted onto the main chain of poly (dichloro phosphazene) substituted phosphorus chloride key, then methoxyethanol substituted the remaining phosphorus chloro key to adjust the proportion of the two substituents, polyphosphazene having a water-soluble, and can control the proportion of aldehyde groups, and then with an aldehyde group with the amino side groups of the gelatin hydrogel directly obtained by the reaction injection. Path synthesis of tyramine and methoxyethoxy were replaced the polyphosphazene, while tyramine or a hydroxy acid phenol grafted hydroxyl, carboxyl or amino reaction with gelatin in the gelatin molecular chain, the polyphosphazene and modified gelatin horseradish peroxidase (HRP) / H2O2 role enzymatic crosslinking reaction can be obtained injectable composite hydrogel stent. This thesis was successfully synthesized aldehyde phenoxy - methoxyethoxy of substituted polyphosphazene, and casein amine - methoxyethoxy of substituted polyphosphazene, and using FT-IR, 1H NMR and intrinsic viscosity number of tests for the characterization of the chemical structure and molecular weight. Will have an aldehyde group, a phenoxy group - methoxyethoxy of substituted polyphosphazene, and gelatin gel experiment were dissolved in phosphate buffer solution (PBS), to change the proportion of the polyphosphazene an aldehyde substituent, two the colors of the polymer solution concentration and mixing ratio of the hydrogel in the gel time can be regulated, water absorption, and so on. Be obtained through path the injectable POLYPHOSPHAZENE / gelatin composite hydrogel through the regulation horseradish peroxidase and H202 amount and proportion, in theory, the gel time, gel strength and performance regulation , this part of the experiment is still in progress. The paper also simulated body fluid (SBF) was evaluated on the biological activity of the amino acid ester substituted polyphosphazene osteogenic. Propionate prepared mainly by electrostatic spinning process, the characteristics of the polyphosphazene molecule of Atomic Energy, phosphorus, nitrogen, etc. to migrate to the surface of the fiber with the polar solvent volatilization, trifluoroethanol, tetrahydrofuran and chloroform, electrospinning Ethyl - glycine ethyl ester of substituted polyphosphazene nanofiber, the contact angle of the test application photoelectron spectroscopy (XPS) X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX ), Fourier transform infrared spectroscopy (FT-IR) were characterized to study the surface of the fiber element composed of different mineralization performance, compared with the results of polylactic acid fiber mineralization. Found: polyphosphazene mineralized material has good performance, the fiber surface of the phosphorus / nitrogen enrichment can affect the occurrence of the mineralization. Supersaturated SBF, after the induction period will into dihydrate calcium hydrogen phosphate (DCPD), and then gradually transformed into hydroxyapatite.

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