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The Study of IL-1 and Erythropoietin in Patients Suffering from Rheumatoid Arthritis with Anemia of Chronic Disease

Author: YuLiJun
Tutor: ZhangWanJiang;WuGuangSheng
School: Shihezi University
Course: Pathology and Pathophysiology
Keywords: Arthritis Rheumatoid Anemia Interleukin- 1 ( IL - 1 ) EPO
CLC: R593.22
Type: Master's thesis
Year: 2011
Downloads: 28
Quote: 0
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Abstract


Objective To investigate the levels of interleukin- 1 ( IL - 1 ) and EPO in rheumatoid arthritis ( RA ) is associated with anemia of chronic disease ( ACD ) and significance . Methods A case-control study to comply with the diagnosis of rheumatoid arthritis patients (aged 25 to 75 years ) for the study to normal health in 30 cases (aged between 35-62 years of age ) as a control group collect the serum of all patients and healthy controls , and patients with clinical data to do a detailed record . Are classified according to the patient 's blood count and erythrocyte sedimentation rate determination and serum ferritin detection of the collected cases of rheumatoid arthritis ( with ACD group of 20 people , with 20 IDA group , anemia group of 30 people ) . Detected by ELISA IL - 1 , EPO level , analysis of the differences between the three groups , and compared with 30 normal subjects . Discussion of IL-1 level and the degree of anemia relationship . Result , the level of IL-1 RA with ACD group was significantly higher than the normal control group , ra ??no anemia group ( P lt ; 0.01 ) , RA with ACD group Epo levels were significantly higher than the normal control group and RA anemia group ( P lt ; 0.05 ) , ferritin RA with ACD group was significantly lower than the RA anemia group ( P lt ; 0.01 ) . RA with ACD group of iron protein was significantly higher than the RA with IDA group ( P lt ; 0.01 ) , no significant difference ( P gt ; 0.05 ) with RA without anemia group between IL - 1 and ESR showed a positive correlation (r = 0.67 , P lt ; 0.05 ) ; groups ferritin was negatively correlated ( r = -0.40 , P lt ; 0.05 ) ; Hb with RA with ACD anemia group was negatively correlated ( r = -0.57 , P lt ; 0.05 ) ; EPO was no significant correlation ( r = 0.15 , P GT ; 0.05 ) . Conclusion IL-1 in the pathogenesis of RA with ACD plays an important role ; relative lack of RA with ACD in vivo EPO , IL-1 may be associated with the impact of iron metabolism and the generation of Epo .

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CLC: > Medicine, health > Internal Medicine > Systemic disease > Autoimmune diseases > Autoimmune diseases, connective tissue disease > Rheumatoid arthritis
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