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Objective: To observe the Kazakh (Kazak) heart failure the plasma copeptin (Copeptin), matrix metalloproteinase -2 (MMP-2) level changes discussed between the two indexes as well as two indicators of cardiac function, left ventricular remodeling relationship. Methods: Consecutive Yili Prefecture in Xinjiang Friendship Hospital, Department of Cardiology, 90 patients were treated from December 2009 to April 2010 Kazak patients with congestive heart failure (CHF group), according to the heart according to the New York Heart Association (NYHA) functional classification standard, sub heart function Ⅱ 25 cases, 35 cases of grade III, Ⅳ grade 30 cases, normal heart function to the same period in hospitalized Kazak 30 patients as a control group. All patients to measure blood pressure, height, weight, fasting blood plasma Copeptin was measured by enzyme-linked immunosorbent assay (ELISA), MMP-2 levels, automatic biochemical analyzer determination of total cholesterol (TC), triglyceride (TG) high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), biochemical indicators. Echocardiographic measurements of left atrial internal diameter (LAD), left ventricular end-diastolic internal diameter (LVEDD), left ventricular ejection fraction (LVEF), fractional shortening (FS), application SPSS13.0 statistical software analysis of each indicator relationship. Results: ① Kazak patients with heart failure the plasma Copeptin level significantly higher than that in the control group (P lt; 0.01). In the heart failure group, the plasma Copeptin level of heart function Ⅳ was significantly higher than the grade III patients with heart function, heart function Ⅲ level higher than the heart function Ⅱ, differences between groups were statistically significant (P lt; 0.01). ② Kazak patients with heart failure plasma MMP-2 levels were significantly higher (P lt; 0.01), heart function Ⅲ the level group Ⅳ plasma MMP-2 levels were significantly higher (P lt; 0.01). The comparison shows that the subgroup of heart failure NYHA Ⅳ plasma MMP-2 levels were grade III group (P lt; 0.01) higher than the heart function, heart function Ⅲ Ⅱ grade (P lt; 0.01) higher than the cardiac function plasma MMP-2 level difference between cardiac function I, NYHA Ⅳ group had no statistical significance (P gt; 0.05). The ③ Kazak patients with heart failure the plasma Copeptin and MMP-2 was significantly positively correlated (r = 0.392, P lt; 0.01). ④ heart failure group Copeption, MMP-2 and LAD, LVEDD was positively correlated (all P lt; 0.01), and LVEF, FS was negatively correlated (all P lt; 0.01). Further age, gender, NYHA class, LAD, LVEDD, LVEF, FS of seven factors stepwise multiple regression analysis, results show NYHA and LVEF were independent related factors Copeptin NYHA and LVEDD MMP-2 independent prognostic factors . Conclusion: 1 Kazak patients with heart failure the plasma Copeptin level with NYHA class progressively increased, and a good correlation with the severity of heart failure, in particular, has good diagnostic value for the early diagnosis of heart failure. ② MMP-2 in patients with heart failure was significantly higher and better reflect cardiac structure and function. The ③ Copeptin, MMP-2 levels in sensitive detection indicators as a clinical diagnosis of heart failure, assessment of cardiac function.
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