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Background breasts are a symbol of feminine beauty, the human dreams through a simple injection filling method plump chest. Therefore, various medical injection products have emerged and continue to come out. In addition to the early years of the wider use of polyacrylamide hydrogel (PAAG) hyaluronic acid, hyaluronic acid mixture, injection products still in the ascendant. However, because the historical limitations of scientific development and many other factors, lead to the injection fill the complications can not be completely avoided; different injection products, technology or methods, clinical complications of various forms and to varying degrees. A considerable part of the more serious complications and even lost a breast. Complications and side effects of the injection breast has aroused great concern. To PAAG, for example, the exact case of the injection technique to form one or several complete cysts in the breast, easier to handle; but more in Xiongru organizations within the multi-gap formation of varying sizes, scattered or series of cyst-like package block, even dispersion to walk as far as the other parts of abdominal wall outside the breast, back and forearm. April 30, 2006, the State Food and Drug Administration issued a document: the full cessation of the production, sale and use of polyacrylamide hydrogel. But according to statistics, as of 2005, the country has more than 50 million people received the injection of PAAG breast, and so far, every year there are still a lot of people to accept PAAG injections and hyaluronic acid and other substances breast. Faced with such a large group of patients, how effective in treating complications of injection breast problems faced by our plastic surgeons. The treatment of injection breast complications, simple aspiration and incision under direct vision clear. The disadvantage of these methods is not exactly clear foreign bodies and necrotic tissue, leading to many cases of repeated surgery, prolonged unhealed; or overkill, removal of too much tissue or even the entire breast. In summary, how to effectively clear the degeneration and necrosis of tissue caused by the injection material and because of injections; the maximum extent save Xiongru organization; restore or reshape the breast shape is eagerly want to study the subject of an orthopedic surgeon. Clinical medicine mature applications dialysis techniques such as hemodialysis, peritoneal dialysis, intestinal dialysis, microdialysis, can in different areas to remove harmful substances inhibiting the inflammatory response, promote the body wound repair. In 1984 Zhu Zhixiang [24] Professor local tissue dialysis can promote the survival of early burn transplanted flap. We envision local microdialysis treatment injection breast complications is equally effective, superior to conventional treatments. The principle of the present study - Partly microdialysis the dialysis drainage tube placed damage the local tissue region, the use of health exists in the local tissue of the nature of the semipermeable membrane having a variety of film (membrane, muscle cell membrane, the base film, myofascial perimysium) as this characteristic of the dialysis membrane, continuous trace perfusion preparation of the dialysis fluid, so that the small molecules in the cell gap in the local tissue (such as inflammatory mediators), and excess water by the principle of passive diffusion into the perfusate, while sinking certain components of the dialysate may also enter the tissue gap. The purpose of this project is in two parts: the first part, the validity of animal studies local microdialysis study its mechanism of action; second part of the effectiveness of the injection breast complications, clinical application of local micro-dialysis treatment. The first part of the method: a New Zealand white rabbits 12, were randomly divided into experimental and control groups, and the establishment of local injury experimental animal model. 2 experimental group dialysate local microdialysis drainage; control group using saline irrigation and drainage. 3 generally observed two groups of experimental animals wound changes. 4 visual observation of the general condition of the two sets of drainage fluid. 5 to collect two sets of drainage fluid were detected perfusion 4h, 10h, 20h, 30h, 45h drainage fluid osmolality, Na, K, CL-, Ca2 and IL-1, IL-6, IL-8, TNF-α concentration. 6 Statistical analysis: use SPSS17.0 statistical software analysis, using a repeated measures design variance analysis, comparison of the concentration of the experimental group and the control group, a separate effect analysis, the groups were compared using two independent samples t-test or t2 test (for unequal variances pm), time points were compared using One-way ANOVA or Welch test (for unequal variances). The selected test level α = 0.05. The second part of a clinical injection breast 33 patients randomly selected 65 breast. 2 lines areola incision, under direct vision clear injection was to clean up the wound cavity drainage tube placed dialysis the residual Xiongru organized, closed wound. 3 external infusion bottle continuous infusion dialysate, the average each breast about 800ml/24h for 24 to 72 h intermittent control (about 4 hours), while folder with drainage drainage fluid outflow. 4 naked eye can see dialysate clear again after foreign body removal surgery for further examination, according to patient requirements, set holidays body or direct closure of the wound. The results of the first part: a local dialysis significantly promote the experimental group, Na, K, CL-, Ca2 ion balance; the 2 local dialysis significantly reduce damage local tissue interstitial fluid inflammatory mediators IL-1, IL-6, IL-8, while increasing damage local tissue interstitial fluid TNF-α; 3 local dialysis can improve not conducive to tissue growth environment, and promote tissue healing statistical analysis was statistically significant. The second part of the method of combining local microdialysis technology and surgical complications of clinical treatment due to injection of PAAG and other medical substances in breast, 33 patients with 65 breast. 1 case of a breast refuse owned holiday body, and the remaining 32 patients with 64 breast set holiday body. 6 months to 5 years of follow-up observation, in addition to three cases in the the breast outside or within quadrant isolated small nodules less than 1cm, I basically normal breast shape. Conclusion 1 using the new ultra slippery microdialysis Bionic local microdialysis catheter and specific dialysate direct role in local tissue, can effectively promote local blood circulation, and metabolites maximize dialysis and drained from the body, reducing necrotic tissue and foreign bodies the accumulation of promote local tissue survival. 2 technical processing of the application of local microdialysis injection breast foreign bodies and necrotic tissue, the effect is reliable, and maximize the retention Xiongru other organizations, to create the conditions for the reshape breasts good shape. 33 patients with 64 breast prosthesis is placed successfully, beautiful morphology reshape the breast.
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