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Stilbene glycosides in the Synthesis of

Author: LiuLi
Tutor: HuChun
School: Shenyang Pharmaceutical University
Course: Medicinal Chemistry
Keywords: Medicinal Chemistry Salvianolic acid Stilbene compounds Glycosylation Synthesis Anti-ischemic
CLC: R284
Type: Master's thesis
Year: 2006
Downloads: 21
Quote: 0
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Abstract


The salvianolic acid compounds Chinese medicine Danshen main active ingredients for anti-ischemic therapy , has a strong anti- lipid oxidation and free radical scavenging effect , can improve ischemic myocardium the PGI 2 / TXA 2 system balance , to promote the opening of potassium channels , calcium antagonism . The salvianolic acid compounds similar chemical structure , most of them containing hydroxy the stilbene- class skeleton , this paper designed and synthesized a series of stilbene compounds and their derivatives , their anti-ischemic activity for salvianolic acid compounds , QSAR relationship between lay a certain foundation . Defects to a certain extent on the physical and chemical properties of hydroxy stilbene compounds on the limited clinical trial , we designed it glycosylation . Phenol ester by Fries rearrangement re-reduction elimination route synthesized three hydroxy stilbene compound : ( E ) -4 - hydroxy- stilbene , ( E) -4 - hydroxy-2 - dimethyl styrene and α β - dihydro-4 - hydroxy-3 - dimethyl styrene. By Perkin condensation decarboxylation routes Synthesis of ( E ) -4 - hydroxy- 4'- methoxy- stilbene . Wholly acetylated sugar is a sugar group donor, and a catalytic amount of POCl 3 catalyzed glycosidation reaction , synthesis of the above hydroxy- stilbene compound glucosidase , galactosidase and galactoside glycosides . 10 glycosides 1 H NMR, ESI / MS confirmatory structure . Evaluation of the synthesis of the biological activity of the compound of the glycoside derivative of the stilbene is underway .

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