Dissertation > Excellent graduate degree dissertation topics show

Swelling Behavior of Amino Acid Ester Modified Poly(NVP-co-MMA) Hydrogels

Author: ZhangJianPeng
Tutor: YinYuJi
School: Tianjin University
Course: Materials Science
Keywords: NVP-MMA copolymer hydrogel Swelling ratio Amidation Ocular-based tissue expander Hydrolysis
CLC: O648.17
Type: Master's thesis
Year: 2012
Downloads: 1
Quote: 0
Read: Download Dissertation

Abstract


Equilibrium swelling degree of the ionic N-Vinyl pyrrolidone-methylmethacrylate copolymer hydrogel was reached within48hours, which was notcommensurate with the rate of growth and development of children’s eyes, resulted inthe multiplethe surgeries for the evisceration or enucleation. The overall objective ofthis project was to provide a kind of ophthalmic tissue filler hydrogel and itspreparation method, which can be able to swell very slowly in the environment ofhuman body fluids. And the release rate of the swelling ability can be regulated.N-vinyl pyrrolidone (NVP) was copolymerized with methyl methacrylate (MMA)with allyMA and EGDM as crosslinking agents and AIBN as the initiator throughbulk polymerization. After polymerization, the neutral copolymer hydrogel wastransformed into an ionized hydrogel by converting–COOCH3groups into COOH.Furthermore, with water-soluble EDC as the catalyst, the carboxyl groups wereconverted partially into amido bonds through the amidation reaction with amino acidesters. Amino acid esters were hydrolyzed very slowly in pHysiological environment,which can achieve a long-term swelling behavior of the NVP-MMA copolymerhydrogels. The efficiency of the amidation reaction was greatly depended on theconcentration of the EDC/NHS and amino acid esters, amidation time andtemperature. The volume swelling degree of the hydrogels was increased more rapidlyin alkaline than in neutral solution because of the accelerated hydrolysis of theintroduced amino acid esters.The vivo experimental results showed that the long-term swelling behavior wasdepended on the tissue fluid in the orbital and periorbital tissue extrusion. Theequilibrium swelling degree of the hydrogel sample in vivo was slightly less than thatin vitro. Different ester copolymer hydrogel possessed the different initial swellingbalancing, which had nothing with the long-term swelling behavior, remained parallelrelationship. The smaller ester-substitution degree was, the more easily the finalequilibrium swelling degree can be reached; the greater ester-substitution degree was,the more difficult the final equilibrium swelling degree can be reached. So we cancontrol copolymer hydrogels long-term swelling time through increasingester-substitution efficiency, to meet the requirements for the children patients withorbital growth and development.

Related Dissertations

  1. Haihong Fruit Vinegar Processing Technology,TS264.22
  2. The Research on the Comprehensive Modification Technology of Rice Protein Enzymatichydrolysis and Graft Copolymerization,TS201.2
  3. A Study on Environmental Behaviors of 2,4-D Butylate,TQ450.2
  4. Cellulose Pretreatment with Ionic Liquid for Enzymatic Hydrolysis,TQ352.1
  5. Research on Biological Modification and Protection Activity of R-Phycoerythin from Porphyra Yezoensis,TS201.21
  6. Study on Colour and Aromatization of Non-smoking Technology for Smoky Meat Products,TS251.43
  7. Study on the Characteristics of Endoproteases and Changes of Main Nitrogenous Components during Brown Rice Germination,TS210.1
  8. Treatment of Tannery Wastewater by Combined Process of Two-stage H/O and Ecological Pond: Study and Practice,X794
  9. Study on Extraction Process and Properties of Collagen Witch Extract from the Skin and Swim Bladder of Bighead Carp,TS254.9
  10. Study on Extraction of Chlorogenic Acid and Preparation of Functional Peptides from Sunflower Seeds,TS255.1
  11. Technological Research on Preparation of High Activity Walnut Pulp by Ultrasonic-compound Enzyme Synergistic Method,TS255.6
  12. Flow injection spectrophotometric determination of organophosphorus pesticides in environmental water research,O657.32
  13. Preparation and Physicochemical Properties of ACE-inhibitory Peptides from Silkworm Pupae Protein,S886.9
  14. The Function of Ribosome Large Protein L11 loop62 During Regulating Protein Translation,Q75
  15. Intensification on Hydrolysis and Esterification Precess by Hydrodynamic Cavitation Technology in Biodiesel Preparation,TE667
  16. Visible oxide catalyst with high activity and mechanism of Design and Synthesis,O643.36
  17. The Enzymatic Preparation and Analysis of Chitooligosaccharides and Its Preliminary Separation,TQ929.2
  18. Fermentative Production of Glutathione by Candida Utilis Using the Hydrolysate of Banana Peels as the Substrate,TQ936.16
  19. Bone peptone peptides and their effects on the distribution of industrial fermentation,TS251.94
  20. Preparation and Characterization and Functional Evaluation of Collagen from Haddock and Pollock Processing By-product,TS254.7
  21. Research on Antioxidant Activity of Silkworm Pupa Peptides and Purification of Antioxidant Peptides,TQ464.7

CLC: > Mathematical sciences and chemical > Chemistry > Physical Chemistry ( theoretical chemistry ),chemical physics > Colloid chemistry ( physical and chemical dispersion system ) > Colloid > Gel and soft
© 2012 www.DissertationTopic.Net  Mobile