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Liposomes are formed by substances such as phospholipids and cholesterol in aqueous solutions , small spherical sac, is a good drug carrier , its has excellent biocompatibility and safety , has its advantages in drug delivery , etc. . Silybin for drug model to study the preparation of liposomes and physical and chemical properties , and silybin solubility in certain organic solvents and their associated drug dissolution and transport properties provide the basis for data and theoretical reference . Including : 1 . Thin film ultrasonic dispersion prepared by silibinin liposomes , dialysis separation of liposomes and drugs , UV - visible first derivative spectrophotometric determination of silymarin liposomes Bin content , calculate the encapsulation efficiency . Encapsulation efficiency was measure , use ratio encapsulation efficiency and particle size distribution of the three main factors : the phospholipids and cholesterol ; The silibinin the dosage ; hydrated types of media . The three factors and four levels of orthogonal experimental formulation optimization . Determine the optimal prescription : lecithin : cholesterol = 100:50 , silybin 10mg, hydrated media 0.01M phosphate buffer solution ( pH = 6.86) , and its encapsulation efficiency was 86.57% . 2 of water silybin liposome physical and chemical properties : IR spectra of the membranes , membrane DSC , the liposome TEM , liposome size distribution, drug release in vitro study of five areas . The results show that : silybin and phospholipids simply compound did not happen chemical shall lecithin cholesterol can inhibit the phase transformation occurs ; membranes DSC can be seen ; TEM liposomal form spherical vesicles , particle size size in between 64.29-250.00nm , the average particle size of 123.48nm; respectively, with zero-order equation , an equation , Higuchi equation , Niebergull square root of the equation , Hixcon-crowell cube root equation , Weibull equation fitting drug release kinetics equation release of the data , the release of the first order kinetic equation . 3 using the solid - liquid equilibrium method silybin solubility in an organic solvent of ethanol, acetone , ethyl acetate , dimethyl formamide , etc. were measured . , Respectively, with the ideal solution model , empirical model the , Apelblat equation model and λh equation model to the experimental data association. Experience the model and Apelblat equation model associated better .
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