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Neonicotinoid compounds are closely associated with the life sciences, with a high level of activity and a wider range of applications. Mainly present in tobacco in organisms, with a wide range of biological activity and medicinal value and have been attentioned, many varieties have been used as herbicides, pesticides, plant growth regulators, intermediates of medicines and drugs are developed and successfully applied. In the food safety problems emerge in an endless stream, on the safety of human life have a great threat today, advocates from "farm" to "table" mode of production, how to reduce pesticide residues, has a very important significance of new pesticide development and production of high efficiency and low toxicity. Development and application of neonicotinoid insecticides for humans increase food production, solving the world’s food supply security issues has made great contribution to Nicotine is the main alkaloid in tobacco plants, and demethylation in the metabolism of nicotine nicotine is an intermediate product in newborn testing out the new nicotine in tobacco and Anabasis alkali, and discover new compared to nicotine and nicotine, has stronger biological activity and higher potential value. In addition, neonicotinoid compounds also works with a number of human diseases and pathological phenomena, such as Parkinson’s disease, presenile dementia, and closely related to mechanisms of onset of pain, the compounds have become important objectives for the development of new drugs, will also become a human plays a crucial role in many neurological diseases. In large amounts on the basis of a literature search, with nicotine as raw materials, via oxidative decarboxylation, get nornicotine with nornicotine as raw material, Design and synthesis Nicotine derivatives; Use3-(Aminomethyl)pyridine and Benzophenone as main raw material, the first synthesis of N-(Diphenylmethylene)-3-PyridinemeThana-mine, then synthesis of Anatabine. With Anatabine as Matrix, Designed and synthesized A series of neonicotinoid compounds. In the synthesis of compounds, which seven species for new compounds, other products of synthesis are for has technology optimization and technology improved, And structure similar to that of antibacterial activity of several compounds have been studied. The work are as follows:With nicotine as raw materials, via oxidative decarboxylation, get nornicotine with nornicotine as raw material, Design and synthesis N-nitrosonornicotine, N-ethanoneethanone and N-carboxymethyl-nornicotine; Use3-(Aminomethyl)-pyridine and Benzophenone as main raw material, choice methylbenzene as addition agent, The first synthesis of N-(Diphenylmethylene)-3-pyridinemethanamine, then synthesis of Anatabine, With Anatabine as Matrix, Designed and synthesized Anabasine, N-Nitrosoanatabine, N-Nitrosoanabasine, N-Methylanatabine, N-Methyl-Anabasine, N-carboxymethyl-anatabine and N-carboxymethyl-anabasine, et al. and exploration has part compounds of synthesis conditions, The structures of new compounds have been characterized and confirmed by1H NMR, FT-IR and Agilent Tandem time-of-flight mass spectrometer.Using filter paper under different concentrations on nicotine, nornicotine, N-nitrosonornicotine, Anatabine, N-Methylanatabine, N-Nitrosoanatabine, Anabasine, N-Methylanabasine and N-Nitrosoanabasine nine species compounds for has subtilis bud hold Bacillus, and Escherichia coli, and Golden Staphylococcus and mold of anti bacteria activity of research and on its inhibition effect for has determination and than on. Results showed that determination of the compound has some antibacterial activity.
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