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Study on the preparation and quality of the cicada snake ointment

Author: YuanJian
Tutor: HuRong
School: Yangzhou University
Course: Of Pharmacy
Keywords: eczema cicala snake paste quality investigation fluorescence analysis
CLC: TQ461
Type: Master's thesis
Year: 2013
Downloads: 18
Quote: 0
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Abstract


Objective:Cicada snake cream preparation and quality study; determination of residence time within the cicada snake cream on the skin and skin penetration rate constant.Methods:Water extraction of volatile oil in drug; By homogeneous emulsion preparation cream; Thin-layer chromatography of osthol on qualitative identification; Reversed-phase high performance liquid chromatography determination of osthole content(Chromatographic column:SinoChrom ODS-AP5μm, long column:250mm, column diameter:4.6μm, detection wavelength:322nm, mobile phase:methanol-water (80:20), pressure lOMPa, velocity lml/min); centrifugal, high temperature, low temperature experimental investigation on emulsion stability.Fluorimetric method as a quantitative tool, through inverted fluorescence micros cope observation and determination of fluorescenc spectrophoto(Scanning mode:EM scan EX wavelength:365nm,EM wavelength:410nm, speed:high speed, sensitivity:2,EX crack width:10nm,EM crack width:10nm), to determine the residence time of cicadas snake cream on the skin and penetration rate constants.Results:Cream produced by nature good appearance, the color is creamy white, fine and smooth, easy painting exhibition. By thin-layer chromatography, test control pink pinkco spectrum and spectrum in the appropriate position, displaying the same colors of fluorescent spots, had been found to contain osthole. By reversed-phase high perfor-mance liquid chromatography determination of osthol content in cream is greater than0.4%. Stability testing, cream no layering, centrifugal rupture phenomena such as milk, cold heat resistance test also demonstrated its stability. All aspects of traditional Chinese medicine compound eczema cream stable nature, could serve as a new develo-pment of eczema treatment preparations, this experiment can be used as a basis for the future application of the preparation. Cicada skin of snake cream rate constant is smaller, according to Ficks the first law, the steady flow of drugs is proportional to the concentration of drug in the skin, this may be related to cicadas of osthol content in lower Snake cream. Greater lag time of preparation, may be because the stratum corneum of the skin is the main barrier of the transdermal absorption of drugs and in the stratum corneum of the skin surface lipid soluble substances are easier to cross, activity of active substance can be entered only after through the stratum corneum skin then is absorbed.

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