Dissertation > Excellent graduate degree dissertation topics show

The Study on the Total Synthetic Technology of Spices Karanal

Author: ZhangZhiXin
Tutor: YinWeiPing
School: Henan University of Science and Technology
Course: Chemical processes
Keywords: Karanal Total Synthesis of Spices Design of OrganicSynthesis Response Surface Analysis Process Optimization
CLC: TQ655
Type: Master's thesis
Year: 2013
Downloads: 13
Quote: 0
Read: Download Dissertation

Abstract


Karanal is an advanced acetal spices with a strong amber aroma, which is mainlyused in daily essence. To the best of our knowledge, there was no reports of Karanal’stotal synthesis to date, therefore, it has great significance to study the Karanal ’s totalsynthesis technique and achieve the industrialized production in the spices industry ofChina. In this study, spices Karanal was prepared by2-methyl diethyl malonate,2-bromobuta-ne and privet aldehyde through alkylation、restore and aldol condensationreactions. Technological parameters of these reactions were optimized through singlefactor method and responses surface analysis. The Intermediates2-methyl-2-sec-butyldiethyl malonate,2-methyl-2-sec-butyl1,3-propanediol and final product Karanalwere analyzed by1HNMR to identify the molecular structure.The researching contentsdescribed as follows：Intermediates2-methyl-2-sec-butyl diethyl malonate [Ⅰ] was prepared by2-methyl diethyl malonate and2-bromobutane through alkylation reaction. The optimumconditions under sodium alkoxide as the catalyzer were determined as follows: themolar ratio was n (2-methyl diethyl malonate): n(Na): n(2-Bromobutane)=1:2:2.2,the reation time was3.5hours and reaction temperature was about65℃. The yield of2-methyl-2-sec-butyl diethyl malonate at the optimal condition was71%.Intermediates2-methyl-2-sec-butyl-1,3-propanediol [Ⅱ] was prepared by2-methyl-2-sec-butyl diethyl malonate through reduction reaction with Na/C2H5OH asreducing agent. The optimum conditions were determined as follows: the molar ratiowas n(Na): n(2-methyl-2-sec-butyl diethyl malonate)=12:1, the reaction time was2hours and reaction temperature was about110℃. The yield of2-methyl-2-sec-butyl-1,3-propanediol at the optimal condition was78.9%.The final product Karanal was prepared by2-methyl-2-sec-butyl1,3-propanedioland privet aldehyde. The optimum conditions under potassium bisulfate as thecatalyzer were determined as follows: the suitable conditions optimized through sigle factor method with temperature at100℃，reaction time at90min, the catalystamounts were3g/mol, and n(privet aldehyde): n(2-methyl-2-sec-butyl1,3-propanediol)was1.2:1．The yield of Karanal at the optimal condition was73.3%.Based on the synthesis technology, this study designed a new methodology andthus achieved the total synthesis for Karanal’s essence. To the best of our knowledge,this is the first study on this topic. The current research on the synthesis ofintermediates [Ⅱ] and Karanal was mostly on mechanistic aspects of organic reaction.The application and industrial production remain as an ongoing challenge. The studyoriginally developed the total synthesis technique of Karanal’s products, which hasestablished a solid foundation for the industrial production of Karanal in China.

Related Dissertations

  1. 1 - deoxynojirimycin synthetic route design and process optimization,TQ463.5
  2. Study on Application of Red Yeast Rice in Fermented Sausage,TS251.65
  3. Strain Screening of Hainanmycin Production and Fermentation Process Optimization,TQ927
  4. Nantong build a modern logistics system of tobacco,F426.8
  5. Tianjin COSCO Logistics ( Tian Rong ) business process optimization and Countermeasures,F552
  6. The Analyzing of Terminal Service Innovation in Gansu Unicom,F626
  7. Sorafenib Synthesis of,TQ463.5
  8. Study on Process Optimization of National HVI Zhoukou Laboratory,F273
  9. A university study process management EMBA teaching project,G647
  10. Research on Inspection Process Optimization of Pingdingshan Boiler & Pressure Vessel Inspection Institute,F203
  11. Study on the Production Process Optimization of Washing Powders in Company NC,F426.72
  12. Automatic Measurement Device of Gauge Block Grade 2 Base on Laser Interference Theory and Evaluation System,F259.2
  13. Optimal Research of Yunfu New Port Business Process Based on Petri Net,F552
  14. Modelling and Engineering Optimization of Ethylene Oxychlorination in Fluidized Bed Reactors,TQ221.21
  15. Research on Laser Scribing Technics for Reducing Core Loss of Grain-oriented Silicon Steels,TG665
  16. Analysis of the Nutritional Components and Study of Total Flavonoids in Xiaoxianggou,R284
  17. Mutation and Application of Raw Starch-Digesting Glucoamylase Strain,TQ925
  18. Study on Protein Degradation Products and Preservation Method for Boiled-pork,TS251.1
  19. Optimization Research and Application of Business Process Based on Web Service,TP18
  20. Study on Optimization for Automatic Pressing Process in Robot System,TP242
  21. Ken Su Galaxy ERP system implementation and impact assessment studies,F270.7

CLC: > Industrial Technology > Chemical Industry > Spices and cosmetics industries > Synthetic perfume
© 2012 www.DissertationTopic.Net  Mobile