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In the present, Essential Hypertension is one of the most common and the highest incidence disease in xinjiang. Essential Hypertension in the particular history of menopause can performance the fluctuation of blood pressure was larger and the stability of hypertensive drugs was worseer, Professor Huang Yongsheng puted forward the main bases of menopausal hypertension is the maladjustment of liver and kidney and the crux is the damage of superficial venues and lymph vessels by poison, which based on tthe principle of adjust measures to local reference review through many years clinical practices. Professor Huang believed the virtual dry treatment is a valid path in treatting menopausal hypertension and thinked Xu-zao-geng-ping powder has definite effect. The results of this study in order to further develop traditional Chinese medicine research lay the foundation for the prevention and control of menopause climacteric hypertension based on the previous heoretical research and clinical observation experimental research.Reference reviewThe essay systematically summarized the advances of menopausal hypertension with TCM and experimental study as follows, the name of disease, the etiology and pathogenesis, syndrome differentiation with differentiation of symptoms and signs, different treatment with differentiation of symptoms and signs.This Essay reviewed the experimental study results on hypertension experimental animal model, menopausal hypertension experimental animal model, menopausal hypertension yin-deficiency inner dryness syndrome experimental animal model.This Essay also summarized the principle of preventing and treating in menopausal hypertension according to the combine traditional Chinese and western medicine medical point and reviewed the pathogenesis and treatment of menopausal hypertension with vascular remodeling.Theory studyThe disease state was different because the different regions and times by putting the environmental factors into the medical model.This paper dicussed on the influence of northwest drying climate from three aspects:etiology and pathogenesis, syndrome, differentiation with differentiation of symptoms and signs, principle-method-recipe-medicines. We puted forward the main bases of menopausal hypertension was the maladjustment of liver and kidney and the crux was the damage of superficial venues and lymph vessels by poison, then putted forward the valid path of treating menopausal hypertension was "The virtual dry treatment". The application of xu-zao-geng-ping powder was effective agent in the treatment of climacteric hypertension, thus widening the research ideas of TCM prevention.Experimental study1The experimental research of animal model1.1The experimental research of copy the menopause hypertension animal modelRandomly divided11months of32SHR rats into SHR group, control group, menopause hypertension model group, through the removal of SHR rats ovaries copy menopause hypertension animal model, using enzyme-linked immune (ELISA) method to detect the serum sex hormone (E2, FSH, LH, T, P) level, the results show that compare with SHR group and control group, the menopause hypertension rats serum E2, T, P decreased (P＜0.05), serum FSH and LH increased (P＜0.05). Made module rats under light microscopy observation of menopause hypertension rat vaginal smear cytology changes, the result conforms to the characteristics of menopausal rats, proves the ovaries, castration thoroughly, which can be evaluation copy successful copy menopause hypertension rat model. 1.2The experimental research of establish menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal modelRandomly divided11months of12menopause hypertension rats into menopause hypertension group, menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal model group, applying artificial dry environment and using the upside-down stimulation, while giving the northwest dryness syndrome food feeding, further establish the menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal model. Compare with menopause hypertension rats, the weight of menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal model rats lose, water quantity increased, urine volume decreased. Using ELISA method to detect the neurotransmitters and hepatic function of rats, the results show that compare with menopause hypertension rats, the CRH, NE, DA,5-HT, ALT and AST of menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal model group were higher, serum E2, T, E2/T score were lower, the result accord with dryness syndrome animal model evaluation related index changes, then to observe rat liver, spleen, adrenal gland, hypothalamus, histomorphology in line with the characteristic of virtual dryness syndrome animal model changes, which can evaluate menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal model is successfully established.1.3The experimental research of menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal model with vascular remodeling ratsThe only13months of age18rats were randomly divided into SHR and menopause hypertension group, menopause hypertension Yin-deficiency with inner dryness syndrome group, the WKY group. Results show that compared with WKY group, SHR group, menopause hypertension group, the menopause hypertension Yin-deficiency with inner dryness syndrome group rats blood pressure levels, LD, MT and MT/LD increased (P＜0.05); Using ELISA method to detect the rat serum levels of MMP-9and TIMP-1level, using immunohistochemical method and RT-PCR detection rat TGF-β1and TGF-β1 mRNA expression in blood vessels, the research results show that compared with WKY group、SHR group、menopause hypertension group,the menopause hypertension Yin-deficiency with inner dryness syndrome group imbalance is aggravating, TGF-β1and TGF-β1mRNA expression in blood vessels, thus speculated that the above two aspects may be menopause hypertension virtual dryness syndrome occurrence and development of vascular remodeling in rats is one of the pathological mechanism, TGF-β1and TGF-β1mRNA expression might be poisonous dry injury is caused by menopause hypertension virtual dryness syndrome is one of the characteristics of vascular remodeling in rats.2The Effects of Xu-zao-geng-ping powder on vascular remodeling in menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal modelThe13months of menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal model rats18were randomly divided into menopause hypertension Yin-deficiency with inner dryness syndrome black group, Xu-zao-geng-ping powder group and valsartan group. Respectively to the irrigation uniform such as distilled water volume more flat, Xu-zao-geng-ping powder and valsartan capsule after60days, observe the following indicators.2.1The effect of Xu-zao-geng-ping powder on biological characterization in rats, the impact of blood pressure and vascular structure in menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal modelXu-zao-geng-ping powder can inhibit menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal blood pressure with age and the rising trend, and menopause hypertension after30days from the drug virtual dry the blank group comparison, there were significant differences, and antihypertensive effect smooth and durable compare with menopause hypertension Yin-deficiency with inner dryness syndrome blank group. The Xu-zao-geng-ping powder can raise LD value, low MT (P＜0.05), improve the dry signs through nourishing Yin for moistening dryness, nourishing blood for dredging collaterals, so as to make it smooth step-down lasting, at the same time can improve the vessels tissue injury in Yin-deficiency with inner dryness syndrome experimental animal model rats.2.2The effect of Xu-zao-geng-ping powder on MMP-9, TIMP-1in menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal modelThis experiment adopts the enzyme-linked method between groups of rats was detected in serum level of MMP-9and TIMP-1. Results show that comparing with menopause hypertension Yin-deficiency with inner dryness syndrome blank group, the MMP-9and TIMP-1values of Xu-zao-geng-ping powder group are lower (P＜0.05), shows that Xu-zao-geng-ping powder can reduce rat peripheral circulation MMP-9level, lower the compensatory increase of TIMP-1, MMP-9and TIMP-1dynamic balance, reduce its degradation of vascular matrix, thereby reversing climacteric hypertension dryness syndrome of vascular remodeling in rats.2.3The effect of xu-zao-geng-ping powder on TGF-β1in abdominalis aorta tissue and TGF-β1mRNA in thoracic aorta tissue of menopause hypertension Yin-deficiency with inner dryness syndrome experimental animal modelBy immune-histochemical method and RT-PCR method for detection of each rat TGF-β1expression and TGF-β1mRNA expression in ratery tissue. Results show that Xu-zao-geng-ping powder may adjust the TGF-β1and TGF-β1mRNA expression in ratery tissue, relieve menopause hypertension virtual dry blood vessel tissue injury in rats, the implementation of menopause hypertension virtual dry reversal of vascular remodeling in rats, the results for "virtual dry treatment" menopause climacteric hypertension virtual effectiveness of dry syndrome in rats provides experiment basis.
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