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The quality of documents and clinical efficacy of Chinese medicine treatment of uterine fibroids evaluation

Author: LiZhiFang
Tutor: XiePing
School: Chengdu University of Traditional Chinese Medicine
Course: Chinese Gynecology
Keywords: TCM Uterine leiomyoma Literature quality Systematic review
CLC: R273
Type: Master's thesis
Year: 2013
Downloads: 12
Quote: 0
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Objectives:To evaluate the literature quality on the uterine fibroids treated by traditional Chinese medicine (TCM), to acess the validity and security systemically of the uterine leiomyoma treated by TCM,to provide evidence-based basis for clinical decisions and further studies.Methods:To collect the clinical reference study literature published from2007-2011. According to the inclusion criteria of literature and includeclinical epidemiology/D.M.E’s principle and methods, we designed the unitive systematic review table of the treatment on uterine leiomyoma, by TCM to evaluation of Controlled Clinical Trial literatural designal quality the uterine leiomyoma treated by TCM.Then utilize the RevMan5.0to procee Statistics and Meta analysis of included studies.Results:104RCTs were included,18of them used for Meta analysis. The results show that there are so many literatures on the uterine fibroids treated by TCM in recent years. Quality is generally not high because of the methods and report. Meta analysis showed that the cassia twig tuckahoe capsule with mifepristone is better on effectiveness,lessening fibroid volume, reducing progesterone and follicle-stimulating hormone than mifepristone alone. The recurrence rate is lower than mifepristone alone. There is no large difference in adverse reactions and reducing estradiol or luteinizing hormone. Palace tumor capsule with mifepristone is better on effectiveness, lessening fibroid volume and lower on recurrence rate than mifepristone alone. The Leigongtengduogan Pian with mifepristone is better on lessening fibroid volume, reducing estradiol, follicle-stimulating hormone and luteinizing hormone than mifepristone alone.Conclusion:It is sure that TCM unites the western medicine is better on effectiveness, lessening fibroid volume, reducing estradiol, follicle-stimulating hormone and luteinizing hormone than the western medicine alone. While adverse reactions and recurrence rate is lower. However, because of the quality of literatures, it can not provide strong evidence for clinical. High quality literatures are needed to increase the strength of the evidence, which can provide Reliable reference for clinical.

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CLC: > Medicine, health > Chinese Medicine > TCM oncology
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