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Objective: By observing the clinical effects in treating Polycystic Kidney Diseasewith the method of San Jie Xiao Ji (SJXJ), exploring the mechanism of Tuyuan ShennangTang (TYSNT) in the treatment of this disease, analyzing the advantages and feasibility oftreating it with combination of traditional Chinese and Western medicine, I intend toprovide new ideas for delaying the condition of Polycystic Kidney Disease.Methods: Select sixty patients whose condition meet the diagnostic criteria ofPolycystic Kidney Disease, then randomly and equally divide them into two groups, theexperimental group and the control group, ensuring each group had30members. Theexperimental was treated with basic treatment and Tuyuan Shennang Tang (TYSNT). Thecontrol was given the same basic treatment and the lovastatin tablet treatment. Thenobserve them for3months to compare their clinical symptoms, signs, changes of urinaryproteins，kidney function, blood lipids, kidney ultrasonography and other changes of bothgroups in24hours pre and post the treatments.Result: After3months of the above treatments, the urinary protein per24hrs of thepatients in the experimental group was significantly reduced (P<0.01), the Scr and BUNwere significantly decreased (P<0.01), for the control group, their urinary protein was alsodeclined (P<0.01), but there was no significant change in Scr and BUN (P>0.05).Comparing with the control group after the treatment, the reduction of the urinary proteinper24hrs, the reduction of Scr and BUN of the experimental group were reducedobviously (P<0.05).Both groups have visible difference in reducing the Cys-C, β2-MG,RBP (P<0.01), but in terms of bettering β2-MG and RBP, the experimental group werebetter than that of the control group (P<0.05).It is also superior to the control group in thereduction of Cys-C (P<0.05). Comparison of kidney of the patients has smaller volume inthe experiment and the control group than pre treatment (P<0.05). After treatment with analysis of variance, kidney volume in the experimental group significantly decreasedcompared with the control group (P<0.05). The CHOL,TG and LDL significantly gotlower of the experimental group (P<0.01), the numerical of HDL increased (P<0.05); TheCHOL, and LDL were decreased of the control group (P<0.01),the numerical of HDLincreased (P<0.05), but the numerical of TG were not significantly decreased (P>0.05);After the treatments, TG and LDL both have more obvious difference in the experimentalgroup (P<0.01), HDL was also improved (P<0.05).But there was no statistical significanceof the reduction of CHOL(P>0.05). In conclusion, for improving the individual symptomsof PKD, total efficacy of Chinese medicine symptoms and the total clinical effects of thepatients, the experimental group were better than the control group (P<0.05).Conclusion: The combined method of San Jie Xiao Ji (SJXJ) and basic treatment canobviously improve the clinical symptoms and signs of patients, improve their life quality,control their kidney volume, retard the increase of the cyst and the secretion of the cystfluid, regulate their lipid metabolism, effectively reduce their urinary protein, creatinineand urea nitrogen, better their renal function in the early stage, relieve their pain, postponethe renal failure. Thus, this combined treatment of traditional Chinese and Westernmedicine has more advantages in treating the disease.
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