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The Comparative Research of Terahertz-wave Spectroscopy for Tumor Tissues

Author: ChenTao
Tutor: HeMingXia
School: Tianjin University
Course: Photonics technology
Keywords: terahertz time domain spectroscopy (THz-TDS) comparative study cancer diagnosis imaging discriminate analysis
CLC: R312
Type: Master's thesis
Year: 2012
Downloads: 3
Quote: 0
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Abstract


Terahertz (short for THz) time domain spectroscopy (THz-TDS) technology, asone of the most potential technology in natural science field, attract more and moreattention in recent years, especially in the field of medicine. Scientists hope that it canplay an important role in the application of cancer diagnosis and burn treatment,benefiting our human beings.The purpose of this research is to diagnose the common cancerous tissue usingTHz-TDS technology and accumulate the experience both in experimental technologyand theory analysis so as to reduce the gap with foreign study. Comparative studymainly reflects in: experimental mode is divided into transmission and reflection type;experimental sample for paraffin embedded and fresh cancer tissue.THz radiation effect, THz spectrum technology and THz imaging technologywere summarized in this paper. Hydration was analyzed in detail based on theknowledge of skin structure and composition, and got the dielectric property of thedifferent state in THz frequency band. Also the model of skin hierarchical and Debyewas introduced. The skin cancer image was obtained using the transmission THz-TDSat1.3THz and explained from the view of pathology. The complex dielectric constantof the canceration area and health area was obtained. Imaging interface was designedusing MATLAB and LabVIEW. Reflex THz-TDS had also made progress. Thespectroscopy of health tissue, basal cell carcinoma tissue and adipose cancer tissuewas obtained using the self-designed8F experiment system. The choice of the lensand parameter and optical fiber dispersion and compensation were demonstrated. Thespectrum of the system was0.15～1.2THz and the spot diameter was3mm, whichmeet the measurement requirements. The canceration area and health were districtedcorrect using the statistics-discriminate analysis. Quantitative detection was realizedusing discriminate analysis and Debye model which laid the foundation for THz-TDSused in clinical in the future.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Medical Physics
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