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Synthesis and Properties of Novel Triazolo [1,5-c] Quinazolines and β-cyano Aromaticamines

Author: LiZuo
Tutor: DingMingWu
School: Central China Normal University
Course: Pesticides
Keywords: Carbodiimide 2,5 - disubstituted 1,2,4 -triazolo 1,5- c ] quinazoline derivatives Aza-Wittig reaction Isocyanate The small column spore ketone dehydratase Bactericidal activity Synthesis
CLC: TQ455
Type: Master's thesis
Year: 2009
Downloads: 31
Quote: 0
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Abstract


Heterocyclic compounds has attracted increasing attention due to a wide range of biological activity , have found many heterocyclic fungicides , herbicides , insecticides and medicine . This paper studies the Application aza-Wittig reaction design and synthesis of novel triazole 7 has not been reported and quinazoline compounds , and explore the spectral properties of the synthesized compounds . In addition, a small column spore ketone dehydratase (SD) the inhibitor cinnolines derivative structure of the pilot , designed and synthesized a β-cyano- aromatic amine derivatives 17 have not been reported , and test some of the compounds biological activity. The specific contents are as follows : 1, using the aza-Wittig reaction of the β-cyano the phosphinimine with isocyanate to give the β-cyano- carbodiimide intermediates , and the selective application of the intermediate with hydrazine hydrate to form a ring for the reaction first times Synthesis of the key intermediate 4 - imine 2 - arylamino -3 - aminoquinazoline derivative 3.3 and the reaction of the isocyanate in the imino form intermediate urea 4.4 PPh 3 < / sub > C 2 Cl 6 , NEt 3 reaction , high yield target compounds 2,5 - disubstituted 1,2,4] triazolo [ 1,5- c ] quinazoline derivative 5, and discussed the mechanism of the ring-forming reaction . Small column spore the ketone dehydratase (SD) inhibitors cinnolines derivatives pilot for structural design and synthetic derivatives 8 17 β-cyano- aromatic amines have not been reported , and preliminary study of the synthesis part of the compound in a concentration of 100 mg / L in vitro antibacterial activity . These compounds the columella spore ketone dehydratase (SD) inhibitory activity and in vivo anti- rice blast fungus activity is being tested .

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CLC: > Industrial Technology > Chemical Industry > Pesticide Industry > Antiseptic
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