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Mannich reaction is considered as aminomethylation,It is an important organic reaction from this century.It has a wide range of values in the medicine and the synthesis of alkaloids,and the reaction of many important organic intermediates.Thus chemists have paid attention to Mannich reaction.Mannich reaction is traditionally used liquid acid as a catalyst,characterized by low yield,difficult separation and complicated operation,but also likely to cause pollution of the environment.In order to avoid the traditional Mannich reaction in the difficult separation for catalyst, corrosion and environmental pollution,and we synthesized silica supported-catalysts, SiO2-OAlCl2 and SiO2-OPCl2.We investigated three components "one-pot" Mannich reaction using acetophenone,aromatic aldehydes and aromatic amines,and three components "one-pot" Mannich reaction using cyclohexanone,aromatic aldehydes and aromatic amines.In addition,We also investigated three components "one-pot" Mannich reaction using substituted acetophenone,aromatic aldehydes and aromatic amines catalyzed by SiO2-OPCl2.Compared to the traditional liquid acids,the silica supported catalysts have advantages of high yield,short reaction,no corrosive, reusability,no pollution.At the same time we also obtained a series of Mannich bases.This paper is divided into four chapters:Chapter 1:IntroductionIn this chapter,we introduce the history of the development of Mannich reaction and development of the catalyst,and importance of Mannich reaction in recent yeas.Chapter 2:silica-supported aluminum chloride catalyed three components "one-pot" Mannich reactions using acetophenone as acid component.We used environmentally friendly catalyst,SiO2-OAlCl2,instead of the traditional liquid acid as a catalyst,of three components "one-pot" Mannich reactions of the aromatic acid components for acetophenone and aromatic aldehydes,aromatic amines.This catalyst is cheap,and easily prepared.Compared with the traditional catalyst,this catalyst has feature of short reaction time,simple work-up procedure, high yield,no pollution,recycle and reusability. Chapter 3:silica-supported aluminum chloride catalyed three components "one-pot" Mannich reaction using cyclohexanone as acid component.We used environmentally friendly catalyst-SiO2-OAlCl2,instead of the traditional liquid acid as a catalyst,of three components "One-pot" Mannich reactions of the aromatic acid components for cyclohexanone,aromatic aldehydes and aromatic amines.This catalyst is cheap,and easily prepared.Compared with the traditional catalyst,this catalyst has feature of short reaction time,simple work-up procedure, high yield,no pollution,recycle and reusability.Chapter 4:silica-supported phosphorus trichloride catalyed three components "one-pot" Mannich reaction using substituted for the acetophenone acid component.We used environmentally friendly catalyst-SiO2-OPCl2 instead of the traditional liquid acid as a catalyst,of three components "one-pot" Mannich reactions of substituted for Acetophenone aromatic acid components,aromatic aldehydes and aromatic amines.This catalyst is cheap,and easily prepared.Compared with the traditional catalyst,has feature of short reaction time,simple work-up procedure,high yield,no pollution,recycle and reusability.Meanwhile,A series of Mannich bases was obtained.
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