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Objective: To evaluate in the early stage of left ventricular (LV) dysfunction, weather LV systolic dysfunction and diastolic dysfunction occur simultaneously or not in patients with type 2 diabetes mellitus (2-DM) using two-dimensional speckle tracking echocardiography imaging (STI). Methods: LV conventional ultrasound parameters were measured in thirty-six patients with 2-DM and forty-five control subjects, and then images were analysised by STI offline. We examined mean peak systole (S), peak early (E’) diastole,peak late (A’) diastole and E’/A’ ratio(E’/A’)of longitudinal strain rate (SrL) on base, middle and apical segments in apical long-axis views, and circumferential strain rate (SrC) and radial strain rate (SrR) in three levers of LV short-axis views respectively. LV torsion parameters such as peak twist (Ptw), time to Ptw, twist at aortic valve closure, twist at mitral valve opening time, untwisting rate, half time of untwisting, peak twist velocity, time to peak twist velocity, peak untwisting velocity, time to peak untwisting velocity were calculated separately in basal and apical LV short-axis views. Results: There was no significant difference in LV conventional ultrasound parameters between 2-DM and control groups. Compared with control group, the S of SrL, E’ of SrL and SrC, and E’/A’ of SrL, SrC andSrR were decreased, meanwhile the S of SrC, A’ of SrL, SrC and SrR were increased in 2-DM group; In addition, Ptw was increased and time to Ptw was shorten in 2-DM group than that in control group,the others of LV torsion parameters were similar between the two groups. Conclusion: In the early stage of LV dysfunction in patients with 2-DM, systolic and diastolic dysfunction occur simultaneously.
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