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Studies on Chemical Constituents of the Kernel of Entada Phaseoloides

Author: ZhangYong
Tutor: ZouZhongMei;SunDiAn
School: Peking Union Medical College , China
Course: Pharmacognosy
Keywords: Leguminous Entada phaseoloides Chemical composition 2,5 - dihydroxyphenyl acetic acid Coumarin α- glucosidase inhibitory activity Anti-HIV activity
CLC: R284
Type: Master's thesis
Year: 2008
Downloads: 22
Quote: 0
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Abstract


From Entada phaseoloides leguminous Ke vine are the seeds of the plant Ke vine Entada phaseoloides (L.) Merr aka glasses beans , Martial Law . Its seeds in the Dai medicine , but few studies of its chemical composition and pharmacological activity . Its chemical composition , its kernel 95% ethanol extracts separated 14 compounds based on spectral analysis ( 1 HNMR, 13 CNMR, HMQC , HMBC, EI-MS) and the identification of their structure . Including two coumarin of : Ke vine lactone A ( entadatin A , EP05 ) , 6 - hydroxy -3,4 - dimethyl- coumarin ( 6 - hydroxy -3 ,4- dimethylcoumarin , EP14 ) ; 6 phenylacetate derivative : 2,5 - dihydroxyphenyl ethyl acetate (ethyl 2,5- dihydroxybenzeneacetate , EP03 ) , 2,5 - dihydroxyphenyl acetic acid methyl ester ( Methyl2 ,5 - dihydroxybenzeneacetate , EP04 ) ,2- O - β - D-glucose -5 - hydroxyphenyl Titanium Dioxide ( butyl2 - O -beta -D - glucopyranosyloxy - 5- hydroxybenzeneacetate , EP11 ) , 5 - hydroxy - benzofuran-2 - one (5-hydroxybenzofuran-2 (3H) . - one , EP15 ) , 2,5 - dihydroxyphenyl acetic acid , n-butyl ( butyl2 ,5 - dihydroxybenzeneacetate , EP16 ) , 2 - O -beta - D - glucose -5 - hydroxyphenyl methyl acetate (methyl2-O- β-D - glucopyranosyloxy - 5 - hydroxybenzeneacetate , EP23 ) ; the three steroid alcohols compound : β - Valley steroid alcohols ( β - sitosterol can be , EP09 ) , carrots glycosides ( daucosterol , EP10 ) , beans steroidal alcohol ( stigmasterol , EP18 ) ; 1 small molecular nitrogen compounds : Ke vine amide A (entadamide A, EP19); 2 fatty acids and esters : stearic acid (stearic acid, EP21), stearic acid methyl ester ( methyl stearate , EP20 ) . EP05, EP11, EP16 is a new compound , EP03 , the EP 10 , the EP 14 , EP 15, EP 18 , EP20 , EP 21 , EP 23 a total of eight compounds isolated from the genus for the first time , EP 09 for the first time isolated from this plant . Entada phaseoloides 95 % ethanol extract of shows the inhibition of α- glucosidase activity . Filter further seed kernels from Entada phaseoloides different extraction portion and a portion of the monomer , the α - glucosidase inhibitor activity , but only the crude extract showed activity . And part of the monomer compounds the screening of anti-HIV activity , which compounds EP03, EP04 and EP16 , EP03, EP04 median inhibitory concentration 9.93μM and 11.7μM inhibit HIV-1 replication of the HIV virus inhibitory activity .

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