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Research on the Protective Effects and Mechanism of Aiweixin Liquid in Myocardial Ischemia-reperfusion Injury in Rat

Author: WangRui
Tutor: WangLu
School: Xinjiang Medical University
Course: Physiology
Keywords: Aiweixin liquid MIRI lipid peroxidation of cellular membrane KATP channel heart function
CLC: R29
Type: Master's thesis
Year: 2009
Downloads: 32
Quote: 0
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Abstract


Objective: To investigate the protective effects and mechanism of Aiweixin on myocardial ischemia reperfusion injury in rats. Methods:Forty Wistar rats, weighting(230~250)g, were divided into four group: sham operation group; Ischemia reperfusion injury group(I/R);Aiweixin precondition group;Aiweixin and Glibenclamide precondition group four groups,each group was 10 rats. The model of MIRI was produced. Recorded the electrocardiogram whole journey:Observed the S-T segment,Q wave,the change of arrhythmia cordis;The heart function were detected through BL-420: LVSP, LVEDPand±dp/dtmax;the cardiac muscle contents of MDA,activity of GSH-PX and the Serum contents of CKwere detected respectively,and the therapeutic effects of Aiweixin liquid were observed in forty rats with MIRI. Results: 1.Aiweixin liquid inhibited the shifting of S-T segment which induced by MIRI.2.Aiweixin liquid improved the hemodynamic changes of MIRI. Aiweixin liquid significantly increased LVSP and±dp/dtmax(P<0.05~0.01),decreased LVEDP(P<0.05).3. the cardiac muscle contents of MDA and the Serum contents of CK were significantly lower(P<0.01), the activity of GSH-PX were significantly higher(P<0.01) ,the occurrence of arrhythmia cordis were soften(P<0.05) in Aiweixin precondition group than that in I/R group. The heart function and cardiac creatase of the Aiweixin and Glibenclamide precondition group and the I/R group were same. 4. Under glossy mirror,the change of morphology of Aiweixin precondition group were softer than the Ischemia reperfusion injury group.Conclusion: Aiweixin liquid could protect MIRI, The myocardial protective mechanism of Aiweixin liquid may be concerned with inhibiting lipid peroxidation of cellular membrane and activating Adenosine Triphosphate sensitivity of potassium channels.

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