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Objective:Modified Zhulingtang observed treatment of diabetic nephropathy IV, clinical efficacy, for the treatment of diabetic nephropathy effective methods and evidence-based medical evidence.Methods:Will meet the inclusion criteria were randomly divided into two groups:treatment group 30 cases,30 cases of the control group. Irbesartan tablets for the control group (An Bowei) 150mg, oral, qd, the treatment group in the control group based on the use of Modified Zhulingtang, one dose a day after meals taking 20min, each about 100ml, 1 Months for a course of treatment, a total of 2 courses. Monitoring body weight before and after treatment in both groups, urine,24h urinary protein, serum albumin, blood urea nitrogen and creatinine, and clinical symptoms of the change.Results:1. The total effective:After treatment, total effective rate was 83.4% in the control group, the total effective rate was 76.6%, both by the X2 test showed significant difference (P<0.05).2. TCM:Syndrome before and after treatment total score group were significantly different (P<0.01), after treatment between the two groups was statistically significant (P<0.05), the treatment group than the control group; two of the symptoms before and after treatment compared TCM There were significant differences (P<0.05), after treatment between the two groups were significantly different (P<0.05), the treatment group than the control group, indicating that the treatment group in the treatment of diabetic nephropathy IV period can significantly improve clinical symptoms.3. Laboratory and relevant examination:body weight before and after treatment,24-hour urinary protein groups were significantly different (P<0.05), treatment group than the control group (P<0.05); the two groups before and after treatment with plasma albumin Significant difference in the treatment group than the control group (P<0.01); after treatment blood urea nitrogen, creatinine, significant difference between both groups (P<0.01), treatment group and control group no significant difference (P> 0.05), that the two groups in improving renal function had no significant difference.Conclusion:Modified treatment of diabetic nephropathyⅣZhulingtang can effectively reduce the edema of the lower urinary protein, increased serum albumin, to improve the clinical symptoms and degree of renal failure in the process, improve patient quality of life.
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