Dissertation > Excellent graduate degree dissertation topics show

A Simulation Study of the Effects of Ischemia to Spiral Waves in 2-D Human Ventricular Tissue

Author: TianHuiLi
Tutor: WangKuanQuan
School: Harbin Institute of Technology
Course: Computer Science and Technology
Keywords: modeling and simulation cardiac arrhythmia spiral wave myocardial ischemia
CLC: R318.0
Type: Master's thesis
Year: 2008
Downloads: 19
Quote: 0
Read: Download Dissertation


Cardiac arrhythmia is the most common heart disease, and one of the main causes of sudden death. The occurrence, development and drug treatment of cardiac arrhythmia are all closely related to the electrical activities of myocardial ion channels. For a long time, the study of the underlying mechanism that lead to cardiac arrhythmia has been a focus for medical and engineering staff. Animal or human experiments and computer simulation are two major types of methods to study the underlying mechanism of arrhythmia. However, the animal or human experiments are time consuming, costly, dangerous, and difficult to get satisfactory results. Along with the development and perfection of mathematical models for cardiac tissue, the use of computer simulation can solve this problem effectively. Use these mathematical models, we can validate of some complex hypotheses, forecast and instruct experimental study in cell level and thereby, complete the work that have difficulty in experimental study. Now, computer simulation has been a method that indispensable in mechanism study of arrhythmia.Based on the newly developed human ventricular myocardial mathematical model, adopted a simulation method that with high simulation accuracy and can accelerate simulation process, and then studied the inherent mechanisms that cause arrhythmia under some pathological conditions. Main content of this paper are as follows:Firstly, three simulation methods was designed for TNNP model[2] which proposed by Tusscher in 2004, based on the simulation results, we compared these methods from computing time, simulation accuracy and numerical stability, then chose a method that has high simulation accuracy and can accelerate the simulation process, in addition, the method was suitable for implementation on personal computer.Secondly, based on TNNP model, with the selected method introduced above, a two-dimensional mesh of human ventricular wall tissue with ischemia symptom was constructed and spiral wave was simulated on the sheet, then studied the wave propagation under different ischemia symptoms, and explained the underlying mechanism that cause arrhythmia under myocardial ischemia in the end of this paper.

Related Dissertations

  1. Research on Mechanism Analysis and Modeling Simulation of Horizontal Well Tractor,P631.83
  2. Research on HID Lamp Rectifying Effect,TM923.32
  3. Steering Mechanism and Hydraulic System for the Electronic Control Hydraulic Power Steering System of Tractor,S219.02
  4. Design and implementation of communication experimental system based on the virtual simulation technology,TP391.9
  5. The Modeling and Simulation of Large-scale Water Conservation Construction Equipment Based on Multi-domain Physical Field Theory,TV53
  6. Simulation and Design of InGaN Solar Cells,TM914.4
  7. Different Doses of Atorvastatin Improve the Forward Blood Flow in the No-reflow Rats Associated with Inflammation,R541
  8. Preliminary Study of the Effect of Cathepsin B Inhibitor CA—O74Me on the Model of Rat Myocardial Ischemia,R965
  9. Simulation-based data correction system evaluation and improvement,TP274
  10. Mechanical electronic and electronically controlled continuously variable transmission system hardware simulation design studies,U463.212
  11. Colored Petri net based workflow engine research,TP311.52
  12. Axial servo loading Test System Design and Research,TH137.9
  13. Ability to detect ballistic missile defense system modeling and analysis,TJ761.3
  14. Compound braking efficiency regenerative braking system stability and energy efficient recovery of,U463.5
  15. Research on Modeling and Simulation of Sea Clutter and Implementation on FPGA,TN955
  16. Research on Public Science Literacy System Based on Multi-agent Simulation Technique,TP391.9
  17. Simulation and Dynamic Analysis on Thermal Power Generation System,TM621.4
  18. Powertrain System Design and Vehicle Performance Simulation of Electric Vehicle,U469.72
  19. Of Railway Vehicle person chairs interface digital design and its ride comfort simulation,U270.387
  20. Quantitative Assessment of Left Ventricular Longitudinal Function in Rabbit Model of Ischemia-reperfusion Injury with Morphine Preconditioning by Strain Rate Imaging,R541

CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues
© 2012 www.DissertationTopic.Net  Mobile