Dissertation > Excellent graduate degree dissertation topics show

Synthesis and Characterization of Intermediates of New Tumor Targeted Amphiphilic MRI Contrast Agent

Author: LvZhiYong
Tutor: YuKaiChao
School: Huazhong University of Science and Technology
Course: Organic Chemistry
Keywords: MRI Contrast Agents Tumor Targeted RGD Peptide Amphiphilic
CLC: TQ463
Type: Master's thesis
Year: 2011
Downloads: 53
Quote: 0
Read: Download Dissertation


Because of its non-invasive, high resolution and good flexibility, MRI has become the most widely used clinical diagnostic imaging technology. With the promotion of MRI, the contrast agent to improve the imaging contrast ratio becomes very important. In this thesis, current research progress of several major T1 MRI contrast agents were introduced (such as enzyme-sensitive contrast agents, metal ions sensitive agents, pH-sensitive contrast agents, cell penetrating and targeting MRI contrast agents, as well as contrast agents with multi hydration number).Integrinαvβ3, which is the receptor protein of RGD peptide, is highly expressed on tumor blood vessls, which made the RGD peptide becomes a novel tumor tageting reagent. It is meaningful work for tumor imaging and cancer treatment that connecting the paramagnetic unit with RGD peptide (and moderate modification) to get a new amphiphilic and tumor targeting MRI comtrast agent. In this thesis, we focused on the synthesis of RGD peptide based amphiphilic MRI congtrast agents for tumor targeting. The main contents are shown as follows:1) An important MRI contrast agent intermediate of DTPA, 1,1,7,7– (tert-butoxycarbonylmethyl) -4- carboxymethyl -1,4,7 - triazine heptane wes synthesised by new designed synthetic route with total yield of 53.9%, This compound has a single actived carboxyl group. Its chemical structure was characterized by spectroscopy method.2) 1,4,7-tritert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane -10-acetic acid, which has a unique carboxyl reaction point, was synthesized. This compound plays an important role in the synthesis of non-ionic contrast agent.3) Two contrast agent ligands were designed, and their prophase synthetic work was finished. These ligands are compose of RGD peptide and long-chain palmitic acid. If coordinated with Gd3+, the complex were expected to be an new amphiphilic and tumor targeted MRI contrast agent.

Related Dissertations

  1. Study of MRI Diffusion-weighted Imaging in the Diagnosis of Lymphadenopathy and Evaluation after Radiotherapy,R445.2
  2. The Application Study of Delay-enhanced MRI in Normal Cartilage and Phase Ⅰ and Ⅱ of Cartilage Lesions of the Knee,R445.2
  3. MRI Study of the Third Ventricle Volume and Width Inhealthy Chinese Adults and Compare to Width in Hydrocephalus,R445.2
  4. Symptoms of Children with Epilepsy and Analysis of MRI-related Changes,R742.1
  5. A Clinical Study of Assessing the Optic Pathway Changes of Glaucoma by Magnetic Resonance Imaging,R775
  6. Lumbar disc herniation in the straight leg raising test and CT, MRI imaging correlation,R681.53
  7. Application of Functional MR Imaging in Diagnose for Prostate Cancer,R737.25
  8. The MRI Application Study of RGD-Gd Targeting Fluorescent Nanoparticle Probe in Vitro Colorectal Cancer Cells,R735.34
  9. Effects of Alcohol Therapy for Acute Spinal Cord Decompression Sickness in Rabbits,R85;R84
  10. Computer-aided Diagnosis System Design and Implementation of Brain Dieases Basing on MRI,TP391.41
  11. The Research on Mri of Contrast Agent Nanoparticles C225-USPIO Marker Targeting to the Nasopharyngeal Carcinoma Xenograft in Nude Mice,R739.63
  12. Used to improve the new nano- carrier for in vivo gene transfection efficacy of linoleic acid and poly malic acid grafted chitosan,R450
  13. Effect of Resistant Starch on the Quality of Quick-Frozen Steamed Bread,R151
  14. In Vitro Evaluation of Two Series of Self-assemble Drug Delivery System Based on the Amphiphilic Polyphosphazene,R943
  15. Magnetic resonance for wireless sensor networks wireless energy transmission system,TP212.9;TM724
  16. Preparation of Thermo-Sensitive Polymeric Micelles Based on Triblock Copolymer Pla-b-Pnipam-b-Pla for Drug Delivery,TQ460.1
  17. Preparation of a Novel Nano Drug Delivery Materials and Its Glucose-Sensitive Properties,TB383.1
  18. The Study of Estimation of Reliability for Complex System and Subsystems’ MRI with Interval Censored Date,O212.1
  19. Amphiphilic just stick - Line Group Molecule Synthesis and properties of aggregates,O561
  20. A Study on Accupuncture Security of Ganshu,R245
  21. Relationship between Imaging Grading of Cervical Spondylosis Myelopathe and Syndrome Type of Traditional Chinese Medicine,R274.9

CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug
© 2012 www.DissertationTopic.Net  Mobile