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Most TCM solid preparation having a different degree of hygroscopicity, mainly for absorbent softened, caking even mildew, hygroscopicity is one of the more difficult to solve the problem of the medicine solid preparation. From the of moistureproof perspective of Chinese medicine solid preparations reported rarely. Absorb moisture to prevent Chinese medicine solid preparations the granulation process improvement and the use of coating process. Compound aloe capsule is commercially available Chinese medicine formulations, rehmannia, medlar, Bupleurum, Angelica, aloe powder and pearl powder Liuwei Chinese medicine treatment of constipation. This product original preparation process system herbs mixed water extraction, water extraction liquid was concentrated drying process handle made of dry extract and add appropriate amount of medicinal powder (Bupleurum and angelica) made of particles, then the particles are made of capsules after the aluminum-plastic packaging. The capsule shell particles with strong hygroscopicity storage period the particles gradually moisture bonded into a group and led to the deformation of the capsule shell (Department of the capsule shell due to dehydration), seriously affecting the stability and clinical applications of this product. Therefore, this product during storage particles moisture is an urgent need to address the problem. The authors have chosen different coating materials and coating methods to study the impact of of Compound Aloe particles hygroscopicity of coated pellets, in order to reduce the compound aloe particles hygroscopicity, to improve the stability of compound aloe capsule purpose. The main contents are summarized as follows: the four flavored herbs (1) Compound Aloe extract preparation process (dry extract) Objective To study the compound aloe four-flavor herbs extraction process, in order to reduce the compound aloe extract (dry extract) hygroscopic purposes. Total flavonoid content indicators, orthogonal experiment were preferred compound aloe water extraction and alcohol extraction process conditions, and on the basis of water extraction conditions, the water extracts for alcohol precipitation process were detected water extraction, alcohol extraction alcohol and water sedimentation technique to extract the dry extract moisture absorption. Results with water as extracting solvent, the best technique for each plus 6 times amount of water, boiling for 2 times, each time boiling 2h. Water extract was concentrated and drying process handle made of dry extract moisture absorption rate of 34.06%. Alcohol extraction solvent, the best technology for each plus 8 times the amount of 80% ethanol, extracted three times, each 3 hours. Alcohol extract by ethanol recovery, concentration, drying Process made of dry extract moisture absorption rate of 30.01%. Water extraction conditions on the basis of the water extract for alcohol precipitation treatment, alcohol solution by ethanol recovery, concentration, drying process handle made of dry extract moisture absorption rate of 28.02%. Conclusions and water extraction process compared to alcohol extraction process and water and alcohol sedimentation technique can reduce the moisture absorption of the compound aloe extract, but not significantly, need to compound aloe extract coating process, in order to further reduce the compound aloe extract hygroscopicity. (2) The best coating materials and the purpose of the coating process, the effects of different coating materials (such as hydroxypropyl methyl cellulose (hydroxy-propyl methylcellulose, HPMC), ethyl cellulose (ethylcellulose, EC), and a polyacrylic acid resin (polyacrylic resin, PR)) and its composite coating particles hygroscopicity of Chinese medicine. Methods using a single material coating, laminating coating (two or three kinds of coating materials are sequentially respectively coated) mixed film coated (two or three kinds of coating material mixed coating), and the mixed film and multiplexed film composite coating methods, the dissolution of the active ingredient in the percentage of coated particles coated particles moisture decreased as the evaluation index, by orthogonal test, screening the best coating method, coating material and its amount. Mixed film and laminating combination coating (the particle moisture absorption decreased by 35.39%) moisture effects than a single material coating (moisture absorption rate decline ≤ 21.82%) the laminating coating (moisture absorption rate of 30.28%) or three coating mixed film coating material combinations (moisture absorption rate decreased by 31.37%) and good (P lt; 0.05). Conclusion mixed film and laminating composite coating method, the mixed membrane composition of EC and PR, the first packet mixed film, after the package HPMC film, significantly reduce the particulate absorbent rate of Compound Aloe, and does not affect the dissolution of the components, thereby improving the Compound Aloe capsule stability, conducive to the production, storage, and application of this preparation.
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