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Through the polycystic ovary syndrome (PCOS) patients with clinical analysis, urinary albumin excretion rate (UAER) and related indicators will be measured to explore this region in patients with clinical features of PCOS, UAER situation and the correlation between. Based on ESHRE / ASRM standard screening by December 2008 to December 2009 received treatment in Tianjin Fifth Central Hospital of Obstetrics and Gynecology 100 patients with PCOS and select healthy women of similar age over the same period 30 cases as normal controls. A case-control study on PCOS patients and healthy control subjects underwent clinical evaluation, serum sex hormone levels, UAER and related metabolic markers to detect and analyze the correlation therebetween. 1.100 cases of PCOS patients clinical features are summarized as follows: oligomenorrhea accounted for 63 percent, accounted for 12% of secondary amenorrhea, irregular menstrual cycle, accounted for 13%, of which oligomenorrhea to the menstrual cycle in 61-180 days as much. Hyperandrogenism accounted for 59%, LH / FSH ≥ 2 accounted for 69%, LH / FSH ≥ 3 accounted for 37 percent, accounted for 44% of acne, hirsutism accounted for 19%, B super-rendered under unilateral or bilateral polycystic ovaries (PCO) accounted for 78%, unilateral or bilateral ovarian volume ≥ 10ml accounted for 25%, obesity (BMI ≥ 25kg/m2) accounted for 43%, central obesity (WHR ≥ 0.85) accounted for 38 %, with insulin resistance (IR) accounted for 49%, acanthosis nigricans combined accounted for 17% of patients with metabolic syndrome accounted for 36%. 2.100 cases of PCOS patients with type Ⅰ PCOS (PCO / HA / IM) patients accounted for 40%, Ⅱ type PCOS (PCO / HA) patients accounted for 9%, Ⅲ type PCOS (PCO / IM) patients accounted for 36%, Ⅳ type PCOS ( HA / IM) patients accounted for 15%. 3.100 cases in adolescent PCOS patients (aged ≤ 19 years), 12% of patients, 88% of patients of childbearing age, including infertility or secondary infertility in 41 cases, accounting for 46.59% of total women of childbearing age. 4.PCOS patient's menstrual cycle, body mass index (BMI), waist-hip ratio (WHR), hirsutism score, ovarian volume, antral follicle count, serum testosterone (T), androstenedione (A2), dehydroepiandrosterone sulfate ketone (DHEA-S), free testosterone index (FTI), luteinizing hormone (LH), luteinizing hormone / follicle stimulating hormone (LH / FSH), fasting plasma glucose (FPG), fasting insulin (FINS). triglycerides ( TG), total cholesterol (TC), homeostasis model assessment of insulin resistance index (HONA-IR) were higher than the healthy control group. PCOS patients with sex hormone binding globulin (SHBG), high density lipoprotein (HDL) than the control group, the difference was statistically significant (P lt; 0.05). 5 performed in 59 patients with PCOS UAER measurement, calculated PCOS patients the incidence of microalbuminuria 8.47% -13.6% in the control group, the incidence of microalbuminuria 6.67% between the two groups microalbuminuria no significant difference in the incidence (P gt; 0.05). 6. PCOS group urinary albumin concentration and urinary albumin / creatinine (ACR) ratio is higher, the difference was statistically significant (P lt; 0.05). 7 The Pearson correlation analysis, PCOS patients with ACR and diastolic blood pressure, BMI, WHR, TG, HOMA-IR index was positively correlated with HDL negative correlation, multiple linear regression analysis, P lt; 0.05 level, diastolic pressure and HOMA-IR index into the equation, as UAER PCOS patients were independent predictors. 1.PCOS concentrated in patients aged 20-35 years old, women of childbearing age is confirmed by a high risk of the disease. 2.ESHRE/ASRM standard basic diagnosis of PCOS appropriate to the region, the new standard amplified two phenotypes have extensive disease groups, accounting for the total number of patients diagnosed with this 45%. PCOS clinical Kaohsiung - Hairy evaluation criteria and the incidence and abroad are quite different. LH / FSH ratio ≥ 2. PCOS is an important biochemical changes and universal, so it can be LH / FSH ≥ 2 as the region PCOS auxiliary diagnostic indicators. 3 in the region of PCOS clinical classification type Ⅰ and Ⅲ as much, and foreign and domestic differences reported in other regions, possibly with PCOS highly heterogeneous, ethnic and regional differences and so on. 4. PCOS incidence of microalbuminuria 8.47% -13.6%, compared with the control group, no significant difference. 5. PCOS patients with urinary albumin concentration and urine albumin / creatinine ratio (ACR) was higher, suggesting that some patients with PCOS has yet to reach the diagnosis of microalbuminuria, which UAER indeed increasing trend. 6. PCOS patients with UAER a correlation between clinical features, including: obesity, central obesity, high TG, low HDL, high insulin resistance. Which HOMR-IR and diastolic blood pressure in patients with PCOS UAER be an independent risk factor.
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