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Objective: To investigate age ≤ 35-year-old young women with cervical cancer incidence, clinical and pathological features, survival rates, the impact of prognostic factors and postoperative quality of life. : 1 for 1999-2008 stay at the Cancer Hospital of Harbin and Harbin Medical University hospital (hereinafter: the two houses), age ≤ 35 years old, 58 cases of young patients with cervical cancer and GT; 35-year-old, 269 cases of cervical cancer in middle-aged The clinical data of cases - the case-control study to examine the relevant factors and clinical and pathological features of young women with cervical cancer. 2 clinical stage I - II of 115 cases of cervical cancer a broad line hysterectomy and pelvic lymph node dissection in patients after clinical pathology and follow-up data, survival rate analysis, univariate and multivariate prognostic factors retrospective analysis. The 3 application FACT-CX Chinese version of the scale investigation of 63 cases of cervical cancer patients with clinical stage I - II a of quality of life (QOL), and the use of multiple regression analysis of factors affecting the quality of life. Result: a clinical and pathological features 1.1 risk factors: patients with cervical cancer are mainly concentrated in the towns and villages, sexual debut age of 21 years old, young group of contraception to the majority of tool contraception and the proportion of oral contraceptives, multiple sexual partners proportion is greater than middle-aged group, but the number of pregnancy is less than the middle-aged group. 1.2 clinical stage: carcinoma in situ in the young group accounted for 10 cases (17.24%, 10/58), Phase I, 31 cases (53.45%, 31/58), the two accounted for 70.69%; carcinoma in situ in the middle-aged group accounted for 20 cases (7.43%, 20/269), Phase I, 89 cases (33.08%, 89/269), both of which accounted for 40.51%. Clinical stage of the two groups in the overall distribution (P = 0.000). 1.3 Clinical manifestations: the young group mainly Contact bleeding in 37 cases (63.79%, 37/58), the middle-aged group irregular vaginal bleeding or postmenopausal vaginal bleeding accounted for 76 cases (28.25%, 76/269). Two groups difference was statistically significant (P lt; 0.05). 1.4 vascular invasion: the younger group were detected in 46 cases, which found that vascular tumor thrombus in 16 cases (34.78%, 16/46), the middle-aged group were detected in 200 cases, which found that vascular tumor thrombus in 40 cases (20.00% , 40/200). The two groups the tumor thrombus overall positive rate difference was statistically significant (P lt; 0.05). 1.5 pelvic lymph node metastasis: 46 cases of pelvic lymph node dissection in the young group, found that pelvic lymph node metastasis in 15 cases (32.61%, 15/46), the middle-aged group of 200 cases of pelvic lymph node dissection, pelvic lymph node metastasis in 37 cases (18.50% 37/200). Two groups pelvic lymph node metastasis rate was statistically significant (P lt; 0.05) 2 clinicopathological factors affect survival 2.1, two groups of patients I - Ⅱ a radical hysterectomy 5-year cumulative survival rate of 82.95%, the young and the middle-aged group, the 5-year cumulative survival rates were 70.27% and 89.31%, respectively, two The difference was statistically significant (P = 0.0386). 2.2 impact of cervical cancer prognostic factors. COX multivariate analysis showed that cervical myometrial invasion, vascular involvement and pelvic lymph node metastasis number of the young and the middle-aged group common prognostic factors, but young women with cervical prognostic factors include tumor diameter. 2.3 factors affecting postoperative survival. Pathological suggestive of cervical myometrial invasion ≥ 1/2, and lymphatic tumor thrombus involving the pelvic lymph node metastasis and vaginal cut end metastasis risk factors. The presence of ≥ 2 risk factors, postoperative radiotherapy or chemotherapy with no treatment survival rates were 83.33% and 16.67%, respectively, the difference was significant (P lt; 0.05). Quality of life and influencing factors young and the middle-aged group, two sets of quality of life score difference was not statistically significant (P = 0.277), but age, place of residence, ovarian transposition, the educational level of the main factors affecting the quality of life. Conclusion: The clinical stage of cervical cancer under the age of 35 with early cancer. Younger group compared with the middle-aged group, no difference in the quality of life, but the survival rate is lower than the middle-aged, and pelvic lymph node metastasis and vascular invasion degree. The presence of ≥ 2 risk factors Adjuvant to the radiotherapy and (or) chemotherapy, can significantly improve survival, but does not improve quality of life. Should strengthen the publicity and promotion of cervical cancer screening for cervical cancer prevention knowledge, so that early diagnosis and early treatment.
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