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Research on the Relationship between Chronic Atrophic Gastritis with Intestinal Metaplasia Syndromes of Traditional Chinese Medicine

Author: FuAFen
Tutor: WuYaoNan
School: Fujian University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: Chronic Atrophic Gastritis(CAG) Intestinal Metaplasia(IM) Intestinal Metaplasia Sub-type Syndromes of Traditional Chinese Medicine(TCM)
CLC: R259
Type: Master's thesis
Year: 2010
Downloads: 166
Quote: 1
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Abstract

Purpose:Through investigation methods of clinic epidemiology to get some guidance to make clinic treatment dialectically and choose more effective schemes of traditional Chinese medicine(TCM) therapy for preventing Gastric Precancerous Lesions,a research in the relationship between chronic atrophic gastritis(CAG) with intestinal metaplasia(IM) and the syndromes of TCM was done to seek the characteristics of the distribution of CAG with IM in clinic TCM syndromes.Objects and methods:279 cases with CAG and IM attacking in Xiamen aera were selected as the research subjects in the out-patient and the ward of Xiamen hospital of TCM in the past more than one year,and,according to the diagnosis of TCM syndromes,classified into four types:disharmony between the liver and stomach,damp-heat in the spleen and stomach, deficiency of the spleen with blood stasis,and deficiency of the spleen with damp-heat and blood stasis. the diagnosis of TCM syndromes was made at the first time patients caming to see us whether they were the first fall sick or recurresce. Then, the data of patients were analyze with statisticsto find out the relationship between CAG with light,mediate or serious IM and sub-type of IM and TCM syndromes in Xiamen aera.Results:1. In TCM Syndromes of the CAG with IM, there were the most patients with deficiency of the spleen and damp-heat and blood stagnation(150/279,53.8%), then the patients with deficiency of the spleen and blood stagnation(91/279,32.6%), the patients with damp-heat in the spleen and stomach(19/279,6.8%),the patients with disharmony between the liver and stomach(19/279,6.8%).2. The proportion of men to women of CAG with IM was 1.05:1 in the observation cases, and there was not significant difference between males and females in the incidence of this disease.3. The main age of getting this disease was 41to 60(166/279,59.5%), mainly was the elderly. The most common course of this disease is 5to10 years (167/279,59.9%), It showed that this disease usually have to undergo a longer process to development.4. There were not significant differences among the distributions of each TCM syndrome in light,mediate or serious IM(P>0.05). 5.There were very significant differences among the distributions of each TCM syndrome in the IM sub-types(P<0.01).Respectively,the distributions of each TCM syndrome in the IM sub-types were as following:omplete IM of small intestine:deficiency of the spleen with blood stagnant> disharmony between the liver and stomach> deficiency of the spleen with damp-heat and blood stagnant> damp-heat in the spleen and stomach;complete IM of large intestine:damp-heat in the spleen and stomach> deficiency of the spleen with blood stagnant> deficiency of the spleen with damp-heat and blood stagnant> disharmony between the liver and stomach;incomplete IM of small intestine:damp-heat in the spleen and stomach > disharmony between the liver and stomach> deficiency of the spleen with damp-heat and blood stagnant> deficiency of the spleen with blood stagnant. Including, there are very significant differences among the deficiency of the spleen with blood stagnant and damp-heat in the spleen and stomach in the IM sub-types(P=0.001<0.0083). Pairwise comparisons between the remaining differences were not significant(P>0.05).6. The incomplete IM of large intestine (Gastric Precancerous Lesions) were all with deficiency of the spleen with damp-heat and blood stasis syndromes.Conclusions:1. In TCM Syndromes of the CAG with IM, there were the most patients with deficiency of the spleen and damp-heat and blood stagnation(150/279, 53.8%), then the patients with deficiency of the spleen and blood stagnation(91/279,32.6%). It prompted that it was unsuitable to treat CAG with IM only using the therapy of reinforcing the body resistance or eminating pathogens,but combining with both of them.The therapies of strenthening spleen,activating the blood and eliminating the stagnant or strenthening spleen,clearing away damp-heat, activating the blood and eliminating the stagnant can be used.2.There was not significant difference between males and females in the incidence rate of this disease(1.05:1), which means both men and women all should pay attention to prevention and treatment this disease.3.CAG with IM occurs in the elderly, usually have to undergo a very long process of development, if we can do early detection and early treatment CAG with IM,we may slow down or even stop the occurrence and development of this disease.4.There were very significant differences among the distributions of each TCM syndrome in the IM sub-types. Respectively,the distributions of each TCM syndrome in the IM sub-types were:omplete IM of small intestine:deficiency of the spleen and blood stagnation> disharmony between the liver and stomach> deficiency of the spleen and damp-heat and blood stagnation> damp-heat in the spleen and stomach;complete IM of large intestine: damp-heat in the spleen and stomach> deficiency of the spleen and blood stagnationt> deficiency of the spleen and damp-heat and blood stagnation> disharmony between the liver and stomach;incomplete IM of small intestine:damp-heat in the spleen and stomach> disharmony between the liver and stomach> deficiency of the spleen and damp-heat and blood stagnation> deficiency of the spleenand blood stagnation. Including, there are very significant differences among the deficiency of the spleen and blood stagnation and damp-heat in the spleen and stomach in the IM sub-types.5.The deficiency of the spleen and amp-heat and blood stagnation was often seen in the CAG with IM patients(150/279,53.8%).The incomplete IM of large intestine(Gastric Precancerous Lesions)were all with deficiency of the spleen and damp-heat and blood stagnation syndromes which perhaps means the possibility of carcinogenesis of this syndrome may be much higher than other TCM syndromes. We should pay more attention to the therapy of strenthening spleen,clearing away damp-heat,activating the blood and eliminating the stagnant when treating CAG with incomplete IM(Gastric Precancerous Lesions)

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