|
Purpose: treatment of wind by Jiawei Xuanbi soup cold dampness Bi ankylosing spondylitis clinical efficacy study and its safety analysis, and, through the mechanism of drug action, the treatment of this type of ankylosing spondylitis and its further development provide the clinical basis; clinical reference for Chinese Medicine of the treatment of ankylosing spondylitis disease diagnosis and treatment programs. Methods: Case inclusion and exclusion criteria, choose our department in March 2008 -2009 in September compliant ankylosing spondylitis patients 60 cases, 30 cases in each experimental group were randomly divided into a control group, the experimental group unified Preparation the flavored Xuanbi soup, the control group were given the same manufacturers Effects of Tripterygium wilfordii tablets, respectively, 12 weeks of treatment, the observed indicators record 0,4,8,12 weeks, through statistical analysis, to verify the flavored soup Xuanbi treatment of cold wet Blockage ankylosing spondylitis clinical efficacy, as well as the evaluation of its safety. Analysis of the parties to explore the mechanism of action of the treatment of AS AS TCM dialectical type. Results: After Sarkozy homosexual examination, no difference in the experimental group and the control group. 2, the experimental and control groups before and after treatment BASDAI, BASFI BASMI, patients and doctors overall evaluation's schober test, chest degree, pillow wall distance refers to distance, ESR, CRP, IgA, PLT observations have significantly improved, indicating that both methods are a good improvement in symptoms of ankylosing spondylitis, delaying the progression of the role. 3, the comparison between groups, BASDAI, BASFI, BASMI, the overall assessment of the patients and doctors, chest, pillow wall from the two groups after treatment, refers to distance, ESR, IgA, PLT, and other indicators have P gt; 0.05 showed that the two treatment methods have almost the same effect. Which schober's test, CRP improved two indicators in the experimental group than the control group (P lt; 0.05). The, pelvic plain film sacroiliac joint performance before and after the treatment of this group, or between groups before and after treatment do not exist significant difference between the two methods has almost the same effect in delaying bone destruction. 5, the total efficiency, two methods were 93.3% and 90%, respectively, by the statistical test P gt; 0.05 in the control penetrance on P lt; 0.05, the experimental group than the control group. 6 security analysis of the two groups were significantly different. From the analysis of adverse reactions, adverse reaction group P-lt; 0.05, the experimental group was significantly lower than the control group. Two treatment methods for ALT, AST, BUN, Cr significantly affect, ALT, BUN, Cr degree of influence of the three comparison are P lt; 0.05, indicating that the control group of liver and kidney function of these indicators, and the experimental group was decreased, while the control group showed an increasing trend, prove the experimental group recipe has a protective effect on the liver and kidney function, higher security. Conclusion: Modified Xuanbi soup can in the near term (three months) to effectively alleviate, improve, and control of wind cold dampness Bi ankylosing spondylitis clinical symptoms, reduce and control inflammation, and significantly improve the quality of life of patients; flavored soup Xuanbi selected according to the dialectical standard cases a good therapeutic effect of wind cold dampness Bi-type AS the debate permit accurate drug card match, some reference value of AS dialectical sub-type; flavored Xuan Bi Tang's security than Tripterygium more glycosides, can effectively avoid the occurrence of adverse reactions.
|