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Coumarin derivative having a sufficiently strong fluorescence intensity, and the large Stocks displacement, a high fluorescence quantum yield and a good solubility, is the most widely studied and the most readily available organic fluorescent material, wherein the coumarins based the fluorescent sensor recent years gradually become a new research focus. The first diethylamino salicylaldehyde and trifluoroacetyl ethyl acetate as raw material, in Hexahydropyridine catalyzed synthesis of 3 - trifluoroacetyl -7 - diethylaminocoumarin. 2,4 - dihydroxy salicylaldehyde and trifluoroacetyl ethyl acetate as raw material, in under Hexahydropyridine catalytic synthesis of 3 - trifluoroacetyl -7 - hydroxycoumarin groping under the above conditions, explore. And then through the 7-position hydroxyl alkylation, a plurality of new fluorinated coumarin ether compound was synthesized. In this thesis, a large number of coumarin and literature as a fluorescent probe gave a detailed introduction and summary, and based on a synthesis of novel trifluoromethyl coumarin fluorescent probe design route. Past, reported more than 4 trifluoromethyl coumarin containing trifluoromethyl coumarin maternal use of substituted phenols and trifluoromethyl-containing compounds occur Pechmann reaction from. 3 - trifluoroacetyl coumarin compounds designed in this topic is the Knoevenagel reaction two step obtained. In this study, 1H NMR, 13C NMR, LC-MS, IR were used to characterize the structure of the compounds, at the same time explore the synthesis conditions, and the reaction conditions were optimized through the use of different solvents, different catalyst came The optimal reaction conditions, the optimal reaction conditions to achieve a high yield. We elected representatives of typical compounds, were carried out the testing and analysis of the UV absorption spectra and fluorescence emission spectra, calculate the fluorescence quantum yield of the compound. Determination of absorption and fluorescence in the ultraviolet divergence spectrum, mainly of nine cations that Mg2, Zn2, Ca2, Cu2, Ni2, Hg2, Co2, Fe3 of Al3 and seven anion NO2-, F-, HSO3 -, Cl-, HSO4-, AcO-, NO3-were measured, wherein in the cation only of Cu2, Ni2 UV absorption, in the fluorescence intensity, the cation has absorption (9 #, 11 # ), in the anion determination of hydrazine hydrochloride None absorption i.e.: # 3 no absorption, while the strength of the hydrazide significantly lower (9 #, 11 #, 12 #).
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