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Study on the Protection Effect of Supramolecular Gel on the Photostability of Drugs

Author: FangFang
Tutor: WangHong
School: Huazhong University of Science and Technology
Course: Analytical Chemistry
Keywords: Supramolecular gels Gelator Vitamin A palmitate Hemin Light stability Protection Release
CLC: TQ460.1
Type: Master's thesis
Year: 2011
Downloads: 7
Quote: 0
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Abstract


Many drugs are unstable under illumination, the photochemical reaction occurs. These reactions may produce a toxic product or intermediate product, resulting in reduced drug efficacy, thus limiting the application of such light-sensitive drug. Benzylidene sorbitol derivatives the gelator prepared supramolecular organic gel and cystine derivatives gelator prepared supramolecular micelles the new carrier hydrogel as easy photolysis drug to vitamin A palmitate, hemin as a model drug, the supramolecular gels light stability of the protective effect of the drug molecules and drug molecules in supramolecular gel diffusion behavior and related mechanism exploration . The results obtained are as follows: 1, using three kinds of benzylidene sorbitol derivatives gelator dibenzylidene sorbitol (DBS), di (methylbenzylidene) sorbitol (MDBS), and bis (3,4 - dimethoxyphenyl Supramolecular organogel yl benzal) sorbitol (DMDBS), 1,2 - propylene glycol / ethanol or PEG / ethanol mixed solvent was prepared, and the light stability of the drug carrier as a protection of vitamin A palmitate (RP). Light 80 minutes after, the MDBS gel in the RP, the relative activity ratio of hydroxyethyl cellulose (HEC) gel was about 60% higher. Gel conditions optimization experiments, the MDBS gel with DBS and DMDBS of gel better protection compared to RP. The protective effect of PEG / ethanol system is superior to the propylene glycol / ethanol system, the PEG content in the mixed solvent to improve the protective effect increased. Gelator concentration and the concentration of the drug there are certain matching relations, both matches, the protective effect of the supramolecular gel RP. 2, the use of field emission scanning electron microscopy (SEM) and fluorescence inverted microscope (FOM) of the micro-structure of the supramolecular gels, supramolecular gels and to explore the mechanism of the protective effect of RP. RP in the three-dimensional network structure in the gel formed the solvent \degradation of the important reasons to have a protective effect. UV spectral data show that by gel wrapped RP chemical structure has not changed. 3, using N-N'-dibenzoyl cysteine ??(DBC) micelle aqueous solution was prepared as a gelator in supramolecular micellar hydrogel systems, the carrier as a drug to protect RP light stability. Anionic surfactant sodium dodecylbenzenesulfonate (SDBS), and a non-ionic surface active agent Tween 80 (Tween 80) the two surfactants, the RP solubilization. The preferred the surplus molecular micelles hydrogel system with orthogonal experiment L9 (3 ~ 4) of the the RP light stability protective effect best system composed of conditions, including the surfactant concentration, RP concentration and DBC concentration. Illumination after 6 minutes, the relative activity of the RP of SDBS micelles supramolecular hydrogel systems than the relative activity of the RP HEC gel higher than about 80%, the RP in the Tween 80 micelles supramolecular hydrogel systems of Relative activity higher than HEC gel the relative activity of the RP, about 60%. 4 1,2 - propylene glycol / water mixed solvent supramolecular gels were prepared using three different benzylidene sorbitol derivatives gel structure factor (DBS, MDBS and DMDBS), as a protection hemin light The stability of the drug carrier. 7 days after the illumination under natural light conditions, hemin supramolecular gels relative activity remained stable, while the aqueous solution of hemin relative activity gradually decreased to about half. 5, DBS, as a model drug the supramolecular gel the the MDBS and DMDBS three kinds of gelator in isopropyl myristate (IPM) as a drug carrier, RP, RP in supramolecular gels release behavior conducted a preliminary study. Gelator concentration and type, RP concentration and temperature on the release behavior of supramolecular gel RP.

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