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The Influence of Apoe on the Electrical Activity of Brain in Acute Phase After Mild/moderate Traumatic Brain Injury

Author: YinXiaoHong
Tutor: SunXiaoChuan
School: Chongqing Medical University
Course: Surgery
Keywords: Apolipoprotein E Brain damage EEG
CLC: R651.15
Type: Master's thesis
Year: 2010
Downloads: 16
Quote: 0
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Abstract


Objective To investigate the apolipoprotein E (APOE) gene on mild to moderate traumatic brain injury in the acute phase of brain electrical activity. Method (1) to collect information of the clinical data of 118 patients with mild to moderate traumatic brain injury patients and 40 normal adults. By polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method to detect the APOE genotype of all subjects; (2), respectively, after injury, 1 ~ 3d and 5 ~ 7d all traumatic brain injury patients EEG detection; sober, quiet, eyes closed, blood sugar normal state under all normal adult EEG detection. (3) qualitative judgment of all traumatic brain injury patients with EEG changes and quantitative data collection of all the research object EEG. (4) using SPSS 11.5 statistical software APOE genotyping results, EEG and clinical data were X2 test, analysis of variance and logistic regression analysis. (1) 40 cases of normal adult the APOEε2, APOEε3 and APOEε4 carriers between quantitative EEG data were not statistically different (P = 0.097); 118 cases of traumatic brain injury patients, EEG activity APOEε2, APOEε3 differences (P = 0.008); between and APOEε4 carriers compared with APOEε3 carriers, APOEε4 carriers slow activity increased significantly slow activity and APOEε2 carriers is relatively small. (2) In order to reduce the impact of the hematoma on the electrical activity of the brain, EEG changes in patients 1 week after further comparison of traumatic brain injury, ruled out expanding intracranial hematoma or delayed-type hematoma in six cases in the detection process patients, a total of 112 patients. Found in 22 cases APOEε4 carriers 12 cases (54.5%) of the EEG deterioration ratio was significantly higher than the non-ε4 carriers (17.8%, P = 0.000); analysis of quantitative EEG data found, after 4 ~ 5d the formal treatment carrying APOEε2, APOEε3 the patients EEG slow wave (P lt; 0.05) reduction before and after twice EEG slow wave APOEε2 carriers reduce the relatively more APOEε3 carriers more significantly (P = 0.025), while the the patients carry APOEε4 EEG slow wave but increased (P = 0.010). Univariate and multivariate logistic regression analysis are indications, APOEε4 the EEG exacerbation risk factors. Conclusion (1) carrying the the different APOE gene normal adult brain electrical activity differences; subtype-specific induced by traumatic brain injury, however, APOE on brain electrical activity; () APOEε4 allele light moderate brain injury patients with acute EEG aggravated risk factors. APOEε4 a negative impact on the electrical activity of the brain after a traumatic brain injury, while APOEε2 conducive to the recovery of the electrical activity of the brain.

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CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Brain > Traumatic brain injury
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