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Studies of Binding Interactions of Ruthenium (Ⅱ) Polypyridyl Complexes Containing Selenium with G-Quadruplex DNA

Author: WuShuo
Tutor: ZhengWenJie；LiuJie
School: Jinan University
Course: Inorganic Chemistry
Keywords: Ruthenium (Ⅱ) Complexes Four-helix DNA Selenadiazole
CLC: O621.13
Type: Master's thesis
Year: 2011
Downloads: 134
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Abstract


Cancer, the medical term known as malignancy, by mechanisms that control cell growth disorders and diseases. In addition to the uncontrolled growth of cancer cells , are also localized into the surrounding normal tissue in vivo circulatory system or even via the lymphatic system to the rest of the body . Human life is like a cancer killer. Currently, there are treatments for cancer traditional Chinese medicine, surgery, radiation therapy and chemotherapy of four. Short chemotherapy chemotherapy, that the use of antineoplastic treatments . Platinum complexes is a relatively excellent anticancer drugs, in order to find low toxicity and low resistance to drugs in recent years, the researchers turned to non- platinum-based drug development , ruthenium complex is one of a . This thesis is based on the previous work , explore and synthesize a series of ruthenium complexes and their structures were characterized . Paper is divided into three chapters. The first chapter is an introduction , describes the development of cancer and cancer treatment methods , ruthenium Polypyridyl research , research progress of organic selenium compounds and solid-phase synthesis principle . Chapter II A series of the general formula [Ru (phen) m (phense) n] 2 (m = 2,1,0. N = 1,2,3) complexes wherein phense = 1,5, 6,10-phenantroline selenide; phen = 1,10-phenantroline, and Ru (phense) 2Cl2 · 2H2O,, and use spectroscopy experiments, including UV - visible , fluorescence, Yuan dichroism three methods studied them with four-helix DNA the role of experiments show that they can be used with four-helix DNA-binding , but also through 1,10 - phenanthroline selenadiazole directly with four helical DNA combined with each other to make four helical conformation of DNA from a mixture of parallel and antiparallel conformation transition the only antiparallel conformation . Chapter III A series of the general formula [Ru (bpy) m (phense) n] 2 (m = 2,1. N = 1,2) complexes wherein phense = 1,5,6,10 - phenantroline selenide; bpy = 2,2 '-Bipyridine, using NMR , MS , UV , fluorescence four kinds of means of their structures were characterized . Studied the mechanism of action with the four-helix DNA . Experiments show that they can be used with four-helix DNA-binding , but also through 1,10 - phenanthroline selenadiazole directly with the four-helix DNA combined with each other to make four helical conformation of DNA from a mixture of parallel and antiparallel conformation into only anti- parallel conformation .

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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Theory of organic chemistry,physical organic chemistry > Organic Chemistry Structure Theory
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