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Study on Synthesis of Pyrimidine Derivatives

Author: GuoFeng
Tutor: ZhuWeiHong；GuHong
School: East China University of Science and Technology
Course: Pharmaceutical Engineering
Keywords: Pyrimidine derivatives 4,6-dimethylpyrimidine 2,4-dichloro-6-methyl-5-nitro pyrimidine synthesis
CLC: TQ455.47
Type: Master's thesis
Year: 2011
Downloads: 306
Quote: 0
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Abstract


The heterocyclic derivatives of pyrimidine have become critical intermediates for drugs, pesticides and organic synthesis. The optimization and improvement of pyrimidine synthesis will greatly promote the development of related industries.In this dissertation,4,6-dimethylpyrimidine was synthesized via one-step reaction, replacing the original two-step reaction which was obtained by the reduction of 2-mercapto-4,6-dimethylpyrimidine with Raney nickel. By optimizing the purification procedure, the purity of the final product can reach 99%, much higher than the commercial available from Aldrich company.Additinally,2,4-dichloro-6-methyl-5-nitropyrimidine was synthesized with the 6-methyl-1H-pyrimidine-2,4-dione as the starting material, through the two steps of nitration and chlorination. It is easily purified with vaccum distillation instead of recrystallization method.The two pyrimidine derivatives are very important pharmaceutical intermediates with bringing good economic benefits due to their high commercial value.

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CLC: > Industrial Technology > Chemical Industry > Pesticide Industry > Antiseptic > Organic fungicides > Heterocyclic compounds fungicide
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