Dissertation > Excellent graduate degree dissertation topics show

Study on Synthesis and Recognition Effect Towards Metal Ions of Fluorine-Containing Coumarins

Author: CaiLi
Tutor: LiHongQi
School: Donghua University
Course: Applied Chemistry
Keywords: coumarins contained fluorine trifluoromethyl fluorescence receptor recognition metal ion
CLC: O621.3
Type: Master's thesis
Year: 2011
Downloads: 263
Quote: 0
Read: Download Dissertation

Abstract


Coumairn moiety has been found to be used in the fields of biology, medicine, perfumes, cosmetics, and laser dyes. The structure of benzopyrone has many advantages including high fluorescence quantum yield, large Stokes shift, excellent light stability, and less toxicity. Coumairn moiety became excellent fluorophore in molecular design for fluorescence chemosensor. By far coumarin derivatives used as fluorescent probes had become hot investigation.Based on reading a larg number of literatures, the paper discussed the synthesis and application in fluorescence chemosensor of coumarin derivatives, and the route for synthesis of novel fluorescence chemosensors based on coumarins containing trifluoromethyl are described in detail. Coumarins containing trifluoromethyl reported were mostly 4- trifluoromethyl coumarins synthesized through Pechmann reaction between phenols and compounds containing trifluoromethyl. In our previous work, we designed to gain 3-trifluoroacetylcoumarins. Because carbonyl in trifluoroacetyl group is more reactive than that in ester group, Knoevenagel condensation did not produce 3-trifluoroacetylcoumarins (1) directly, but 2-hydroxyl-2-trifluoromethyl-3- ethoxycarbonyl-2H-1-chromenes (1). Then we treated chromene 1 with TsOH-H2O (2 mol%) in chlorobenzene to afford coumarin 2 in high yield. Finally, the novel fluorescent probes (3-12) were prepared from coumarin (2a) with compounds containing amino in chlorobenzene for 0.5-6 h.The structures of the new compounds were characterized with 1H NMR,13C NMR,19F NMR, MS, IR and single crystal X-ray diffraction. The reaction conditions were studied in order to find the optimal one of high yield. The absorption and fluorescent emission spectras of typical compounds were tested and analysized, and the fluorescent quantum yields were calculated too.The absorption and emission spectra of chemosensor 9,11 and 12 upon addition of equal equivalent different metal ions (Mg2+, Zn2+, Ca2+, Cu2+, Ni2+, Hg2+, Co2+, Fe3+, Al3+) were tested respectively. Upon addition of Cu2+ or Ni2+ to 11, a blue shift or a bathochromatic shift of the absorption band was observed while the emission band blue-shifted with decrease in the fluorescence intensity. In the presence of Cu2+ the color of the solution of 11 changed from orange to red obviously. Therefore 11 could be used as an optical chemosensor for Cu2+ with high sensitivity.

Related Dissertations

  1. The Classification of High Dimsnsion Flew Field Based on Manifold Learning,V231.3
  2. Study on the Echo Processing Method for the Measurement of Wire Length Based on Pulsereflection,TM247
  3. Multiple ANN/HMM Hybrid Used in Speech Recognition,TN912.34
  4. The Design of a DSP-Based Robot Speech Command Recgnition System,TN912.34
  5. ISAR Imaging Simulation of Space Targets and Target Recognition Based on ISAR Images,TN957.52
  6. Research on Multi-Sensor Embattling and Continious Tracking Technique Applying for Anti-Stealth and Anti-Interference,TN953
  7. Research on Algorithms of 2D Face Template Protection,TP391.41
  8. Research on Intelligent Learning-Based Multi-Sensor Target Recognition and Tracking System,TP391.41
  9. Research on Image Recognition Algorithm in the Forest Fire Prevention System,TP391.41
  10. Study on Virtual Detector of Infrared Hyper-Spectral Image,TP391.41
  11. Research on Temporal Information Recognition and Normalization,TP391.1
  12. Research on Text Classification Based on Biomimetic Pattern Recongnition,TP391.1
  13. Research on the Image Real-Time Acquisition, Storage and Image Processing System,TP391.41
  14. Multi-currency Notes Technology Research and Implementation,TP391.41
  15. Photosynthetic Apparatus Response to Heat Stress and the Mechanisms in Two Different Cotton with Various Leaf Colours,Q945.11
  16. The Treatment Effect and Mechanism of Ketanserin on Inflammatory and Neuropathic Pain,R741
  17. Aerial Target Anti-interference Recognition and Tracking System,TN215
  18. Thermal Stability of Complexes of Chitosan Quaternary Ammonium Salt and Metal Ion,O634
  19. The Investigations on the Characteristics and Mechanism of NIR Emission from Bi-doped Silicophosphate Glasses,TQ171.1
  20. The Antioxidative Efficient Component Recognition for Curcuma Longa L. Based on the Quality Control Pattern of Constituent Knock-out/Knock-in,R285
  21. Flexible,rigid,Synthesis and characterization of mixed ligand complexes,O621.1

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Synthetic organic chemistry
© 2012 www.DissertationTopic.Net  Mobile